BRD-K57080016_-666_A375_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K57080016_-666_A375_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
BLNK B-cell linker
BTG2 BTG family, member 2
CLU clusterin
DLK1 delta-like 1 homolog (Drosophila)
FGFR3 fibroblast growth factor receptor 3
GLUL glutamate-ammonia ligase
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
MYLK myosin light chain kinase
MYO1D myosin ID
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
SESN1 sestrin 1
SOX2 SRY (sex determining region Y)-box 2

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CCND1 cyclin D1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COL4A2 collagen, type IV, alpha 2
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EDNRB endothelin receptor type B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PXN paxillin
SFRP1 secreted frizzled-related protein 1
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC43A3 solute carrier family 43, member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP1 topoisomerase (DNA) I
VCAN versican