BRD-K56957086_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

136 genes differentially expressed following the BRD-K56957086_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ADGRE5 adhesion G protein-coupled receptor E5
ALDOC aldolase C, fructose-bisphosphate
C14ORF132 chromosome 14 open reading frame 132
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CEMIP cell migration inducing protein, hyaluronan binding
CHMP1B charged multivesicular body protein 1B
DGKA diacylglycerol kinase, alpha 80kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EZR ezrin
FAM117A family with sequence similarity 117, member A
FAM171A1 family with sequence similarity 171, member A1
FOXO4 forkhead box O4
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRK5 G protein-coupled receptor kinase 5
GSTA4 glutathione S-transferase alpha 4
HECA headcase homolog (Drosophila)
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
IL2RG interleukin 2 receptor, gamma
INA internexin neuronal intermediate filament protein, alpha
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCTD5 potassium channel tetramerization domain containing 5
KIF5C kinesin family member 5C
LCK LCK proto-oncogene, Src family tyrosine kinase
LPIN1 lipin 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MGST3 microsomal glutathione S-transferase 3
MLF1 myeloid leukemia factor 1
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NLRP2 NLR family, pyrin domain containing 2
NMT2 N-myristoyltransferase 2
NPC1 Niemann-Pick disease, type C1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G15 phospholipase A2, group XV
PRKCA protein kinase C, alpha
PRUNE2 prune homolog 2 (Drosophila)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RIMS3 regulating synaptic membrane exocytosis 3
ROGDI rogdi homolog (Drosophila)
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
STXBP1 syntaxin binding protein 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDTC1 WD and tetratricopeptide repeats 1
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BCAS3 breast carcinoma amplified sequence 3
C2CD5 C2 calcium-dependent domain containing 5
CCND1 cyclin D1
CD58 CD58 molecule
COMT catechol-O-methyltransferase
CRYAB crystallin, alpha B
DUT deoxyuridine triphosphatase
ESR1 estrogen receptor 1
EXOSC8 exosome component 8
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
GTF3A general transcription factor IIIA
GTPBP8 GTP-binding protein 8 (putative)
IGF1R insulin-like growth factor 1 receptor
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LMNB1 lamin B1
LY6E lymphocyte antigen 6 complex, locus E
MLPH melanophilin
MRPS30 mitochondrial ribosomal protein S30
MTMR1 myotubularin related protein 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PGLS 6-phosphogluconolactonase
PRR7 proline rich 7 (synaptic)
PUF60 poly-U binding splicing factor 60KDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SPDEF SAM pointed domain containing ETS transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TCERG1 transcription elongation regulator 1
TP53 tumor protein p53
TPBG trophoblast glycoprotein
TRIP6 thyroid hormone receptor interactor 6
TTC39A tetratricopeptide repeat domain 39A
TYMS thymidylate synthetase
USP22 ubiquitin specific peptidase 22
VBP1 von Hippel-Lindau binding protein 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
XBP1 X-box binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZHX2 zinc fingers and homeoboxes 2
ZMYND8 zinc finger, MYND-type containing 8