BRD-K56957086_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K56957086_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ALDOC aldolase C, fructose-bisphosphate
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND3 cyclin D3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CIB1 calcium and integrin binding 1 (calmyrin)
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
CYTH1 cytohesin 1
DUSP6 dual specificity phosphatase 6
ELOVL5 ELOVL fatty acid elongase 5
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HN1 hematological and neurological expressed 1
HPSE heparanase
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
LAMP1 lysosomal-associated membrane protein 1
LIMCH1 LIM and calponin homology domains 1
MCOLN1 mucolipin 1
MPDZ multiple PDZ domain protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PFKM phosphofructokinase, muscle
PLA2G15 phospholipase A2, group XV
POLB polymerase (DNA directed), beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
RAD9A RAD9 homolog A (S. pombe)
RNF167 ring finger protein 167
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGK1 serum/glucocorticoid regulated kinase 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STXBP1 syntaxin binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
TMED2 transmembrane emp24 domain trafficking protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBA4A tubulin, alpha 4a
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOA2 apolipoprotein A-II
ARPP19 cAMP-regulated phosphoprotein, 19kDa
COL6A2 collagen, type VI, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
DPT dermatopontin
EIF5 eukaryotic translation initiation factor 5
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
EPCAM epithelial cell adhesion molecule
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GPER1 G protein-coupled estrogen receptor 1
GSAP gamma-secretase activating protein
GTPBP8 GTP-binding protein 8 (putative)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1R2 interleukin 1 receptor, type II
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMC1 laminin, gamma 1 (formerly LAMB2)
LOX lysyl oxidase
MAPK13 mitogen-activated protein kinase 13
MSLN mesothelin
MYRF myelin regulatory factor
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PRR7 proline rich 7 (synaptic)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VIL1 villin 1
ZBTB20 zinc finger and BTB domain containing 20
ZHX2 zinc fingers and homeoboxes 2
ZMYND11 zinc finger, MYND-type containing 11
ZMYND8 zinc finger, MYND-type containing 8