BRD-K56957086_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K56957086_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
C9ORF16 chromosome 9 open reading frame 16
CALD1 caldesmon 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CETN2 centrin, EF-hand protein, 2
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL11A1 collagen, type XI, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CXADR coxsackie virus and adenovirus receptor
CYB5R1 cytochrome b5 reductase 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR7 7-dehydrocholesterol reductase
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DSTN destrin (actin depolymerizing factor)
DUSP14 dual specificity phosphatase 14
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GLRX glutaredoxin (thioltransferase)
GMCL1 germ cell-less, spermatogenesis associated 1
GNAS GNAS complex locus
GNS glucosamine (N-acetyl)-6-sulfatase
GSDMB gasdermin B
HMG20B high mobility group 20B
HSPA1A heat shock 70kDa protein 1A
KCNK3 potassium channel, two pore domain subfamily K, member 3
MOSPD1 motile sperm domain containing 1
MT1X metallothionein 1X
NEU1 sialidase 1 (lysosomal sialidase)
OAT ornithine aminotransferase
OSBPL10 oxysterol binding protein-like 10
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PLA2G15 phospholipase A2, group XV
REEP1 receptor accessory protein 1
RIMS3 regulating synaptic membrane exocytosis 3
RNASE6 ribonuclease, RNase A family, k6
ROGDI rogdi homolog (Drosophila)
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCPEP1 serine carboxypeptidase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNN stannin
SOX11 SRY (sex determining region Y)-box 11
STXBP1 syntaxin binding protein 1
SUSD4 sushi domain containing 4
TIMP3 TIMP metallopeptidase inhibitor 3
TPST2 tyrosylprotein sulfotransferase 2
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOXA10 homeobox A10
IGF1R insulin-like growth factor 1 receptor
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
LAMC1 laminin, gamma 1 (formerly LAMB2)
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
NBN nibrin
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTX3 pentraxin 3, long
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
RHOBTB1 Rho-related BTB domain containing 1
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPK1B uroplakin 1B
USP22 ubiquitin specific peptidase 22
WDR43 WD repeat domain 43
ZBTB38 zinc finger and BTB domain containing 38
ZMYND11 zinc finger, MYND-type containing 11