BRD-K56957086_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K56957086_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ANOS1 anosmin 1
BZW2 basic leucine zipper and W2 domains 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLU clusterin
CSRP1 cysteine and glycine-rich protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
G6PD glucose-6-phosphate dehydrogenase
GLRX glutaredoxin (thioltransferase)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HOPX HOP homeobox
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL32 interleukin 32
ITM2A integral membrane protein 2A
KCTD5 potassium channel tetramerization domain containing 5
KIF5C kinesin family member 5C
LIPA lipase A, lysosomal acid, cholesterol esterase
MAN2B1 mannosidase, alpha, class 2B, member 1
MGP matrix Gla protein
MGST3 microsomal glutathione S-transferase 3
MT1G metallothionein 1G
MT1X metallothionein 1X
MT2A metallothionein 2A
MVP major vault protein
NFIL3 nuclear factor, interleukin 3 regulated
NOSIP nitric oxide synthase interacting protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RHOB ras homolog family member B
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATF1 activating transcription factor 1
ATXN10 ataxin 10
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND1 cyclin D1
CHMP4A charged multivesicular body protein 4A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FAIM Fas apoptotic inhibitory molecule
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GATAD1 GATA zinc finger domain containing 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GSAP gamma-secretase activating protein
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
IGFBP6 insulin-like growth factor binding protein 6
ILF3 interleukin enhancer binding factor 3, 90kDa
ING3 inhibitor of growth family, member 3
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LPL lipoprotein lipase
LRRC41 leucine rich repeat containing 41
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICALL1 MICAL-like 1
MOK MOK protein kinase
MSMB microseminoprotein, beta-
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PER2 period circadian clock 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SCAND1 SCAN domain containing 1
SCRN1 secernin 1
SENP6 SUMO1/sentrin specific peptidase 6
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TRIB3 tribbles pseudokinase 3
USP22 ubiquitin specific peptidase 22
VEGFA vascular endothelial growth factor A