BRD-K56653679_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K56653679_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD4 abhydrolase domain containing 4
AKAP8 A kinase (PRKA) anchor protein 8
ANKRD10 ankyrin repeat domain 10
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CASP4 caspase 4, apoptosis-related cysteine peptidase
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN10 claudin 10
CNN3 calponin 3, acidic
COTL1 coactosin-like F-actin binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EDNRA endothelin receptor type A
ELANE elastase, neutrophil expressed
FABP7 fatty acid binding protein 7, brain
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GMPR guanosine monophosphate reductase
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NAP1L1 nucleosome assembly protein 1-like 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
OSBPL3 oxysterol binding protein-like 3
PDZD2 PDZ domain containing 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
QPRT quinolinate phosphoribosyltransferase
RABGGTB Rab geranylgeranyltransferase, beta subunit
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SEPT6 septin 6
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SPARCL1 SPARC-like 1 (hevin)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
TEX10 testis expressed 10
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TXNL4B thioredoxin-like 4B
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AGTR1 angiotensin II receptor, type 1
ALOX5 arachidonate 5-lipoxygenase
ANPEP alanyl (membrane) aminopeptidase
APP amyloid beta (A4) precursor protein
ASB13 ankyrin repeat and SOCS box containing 13
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BLCAP bladder cancer associated protein
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNB1 cyclin B1
CD24 CD24 molecule
CKAP4 cytoskeleton-associated protein 4
CPNE3 copine III
CTBP2 C-terminal binding protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DST dystonin
DUOX2 dual oxidase 2
EFHD1 EF-hand domain family, member D1
EFS embryonal Fyn-associated substrate
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM63A family with sequence similarity 63, member A
GATA3 GATA binding protein 3
GRWD1 glutamate-rich WD repeat containing 1
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
IGF1R insulin-like growth factor 1 receptor
KDM4B lysine (K)-specific demethylase 4B
KHNYN KH and NYN domain containing
KIAA0930 KIAA0930
KIF1B kinesin family member 1B
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LITAF lipopolysaccharide-induced TNF factor
MAOA monoamine oxidase A
MBP myelin basic protein
MCOLN1 mucolipin 1
MEGF9 multiple EGF-like-domains 9
MKI67 marker of proliferation Ki-67
MLEC malectin
MLPH melanophilin
MREG melanoregulin
MTDH metadherin
MUC1 mucin 1, cell surface associated
NCOA3 nuclear receptor coactivator 3
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPAP2C phosphatidic acid phosphatase type 2C
PRKCD protein kinase C, delta
PSD3 pleckstrin and Sec7 domain containing 3
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SEPP1 selenoprotein P, plasma, 1
SET SET nuclear proto-oncogene
SETBP1 SET binding protein 1
SMAD3 SMAD family member 3
SNN stannin
SORBS2 sorbin and SH3 domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SVIL supervillin
SYNM synemin, intermediate filament protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMF1 TATA element modulatory factor 1
TNS3 tensin 3
TXLNA taxilin alpha
ZCCHC24 zinc finger, CCHC domain containing 24