BRD-K56653679_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

274 genes differentially expressed following the BRD-K56653679_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKAP8 A kinase (PRKA) anchor protein 8
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARC activity-regulated cytoskeleton-associated protein
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BCHE butyrylcholinesterase
BGN biglycan
BTG3 BTG family, member 3
C1QB complement component 1, q subcomponent, B chain
CACYBP calcyclin binding protein
CAV1 caveolin 1, caveolae protein, 22kDa
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CECR1 cat eye syndrome chromosome region, candidate 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
COTL1 coactosin-like F-actin binding protein 1
CPE carboxypeptidase E
CTAG2 cancer/testis antigen 2
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCX doublecortin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DZIP1 DAZ interacting zinc finger protein 1
ECM1 extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
EPCAM epithelial cell adhesion molecule
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP11 FK506 binding protein 11, 19 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
H3F3B H3 histone, family 3B (H3.3B)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFI30 interferon, gamma-inducible protein 30
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
INSM1 insulinoma-associated 1
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MIR22HG MIR22 host gene
MPP1 membrane protein, palmitoylated 1, 55kDa
MSX1 msh homeobox 1
MT1F metallothionein 1F
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAP1L1 nucleosome assembly protein 1-like 1
NNMT nicotinamide N-methyltransferase
NOL7 nucleolar protein 7, 27kDa
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
PCDH17 protocadherin 17
PCM1 pericentriolar material 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM1 PDZ and LIM domain 1
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB21 RAB21, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RANBP9 RAN binding protein 9
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
S100A10 S100 calcium binding protein A10
SAP18 Sin3A-associated protein, 18kDa
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIK1 salt-inducible kinase 1
SMIM7 small integral membrane protein 7
SRGN serglycin
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCERG1 transcription elongation regulator 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TEX10 testis expressed 10
TMSB15A thymosin beta 15a
TSPYL2 TSPY-like 2
TXNL4B thioredoxin-like 4B
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
WSB1 WD repeat and SOCS box containing 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABLIM1 actin binding LIM protein 1
ACSL1 acyl-CoA synthetase long-chain family member 1
AHNAK AHNAK nucleoprotein
APMAP adipocyte plasma membrane associated protein
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASB13 ankyrin repeat and SOCS box containing 13
AUTS2 autism susceptibility candidate 2
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BCL2A1 BCL2-related protein A1
BCR breakpoint cluster region
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BST2 bone marrow stromal cell antigen 2
C11ORF21 chromosome 11 open reading frame 21
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK19 cyclin-dependent kinase 19
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CPNE3 copine III
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
EFR3A EFR3 homolog A (S. cerevisiae)
EFS embryonal Fyn-associated substrate
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FAM63A family with sequence similarity 63, member A
FASN fatty acid synthase
FLNB filamin B, beta
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
HOXC6 homeobox C6
HSPG2 heparan sulfate proteoglycan 2
ICMT isoprenylcysteine carboxyl methyltransferase
IGF1R insulin-like growth factor 1 receptor
IL1RN interleukin 1 receptor antagonist
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KANK1 KN motif and ankyrin repeat domains 1
KDM4B lysine (K)-specific demethylase 4B
KDM5D lysine (K)-specific demethylase 5D
LTBP3 latent transforming growth factor beta binding protein 3
MAT2B methionine adenosyltransferase II, beta
MEGF9 multiple EGF-like-domains 9
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MKL2 MKL/myocardin-like 2
MLEC malectin
MME membrane metallo-endopeptidase
MREG melanoregulin
MRPS12 mitochondrial ribosomal protein S12
MSL1 male-specific lethal 1 homolog (Drosophila)
MSRB2 methionine sulfoxide reductase B2
NAV2 neuron navigator 2
NCOA3 nuclear receptor coactivator 3
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME3 NME/NM23 nucleoside diphosphate kinase 3
NPTN neuroplastin
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP210 nucleoporin 210kDa
OSBPL8 oxysterol binding protein-like 8
OXLD1 oxidoreductase-like domain containing 1
OXTR oxytocin receptor
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP2 poly(rC) binding protein 2
PCYOX1L prenylcysteine oxidase 1 like
PDLIM4 PDZ and LIM domain 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLIN1 perilipin 1
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRSS23 protease, serine, 23
RBBP4 retinoblastoma binding protein 4
RERE arginine-glutamic acid dipeptide (RE) repeats
RHOQ ras homolog family member Q
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RXRA retinoid X receptor, alpha
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SELT selenoprotein T
SEPHS1 selenophosphate synthetase 1
SET SET nuclear proto-oncogene
SLC35E2B solute carrier family 35, member E2B
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD3 SMAD family member 3
SNN stannin
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SREBF1 sterol regulatory element binding transcription factor 1
SRPX sushi-repeat containing protein, X-linked
SRRM2 serine/arginine repetitive matrix 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SVIL supervillin
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM164 transmembrane protein 164
TMEM43 transmembrane protein 43
TNC tenascin C
TSKU tsukushi, small leucine rich proteoglycan
TSPAN6 tetraspanin 6
VGLL4 vestigial-like family member 4
WFDC2 WAP four-disulfide core domain 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZBTB16 zinc finger and BTB domain containing 16
ZNF652 zinc finger protein 652