BRD-K56593336_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K56593336_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ATF3 activating transcription factor 3
CD44 CD44 molecule (Indian blood group)
CHI3L2 chitinase 3-like 2
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP5 dual specificity phosphatase 5
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IL1R2 interleukin 1 receptor, type II
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LPAR1 lysophosphatidic acid receptor 1
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PRNP prion protein
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SRGN serglycin
TALDO1 transaldolase 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADGRG6 adhesion G protein-coupled receptor G6
BMI1 BMI1 proto-oncogene, polycomb ring finger
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL10A1 collagen, type X, alpha 1
CREB1 cAMP responsive element binding protein 1
DES desmin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FBP1 fructose-1,6-bisphosphatase 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM3 interferon induced transmembrane protein 3
IGHM immunoglobulin heavy constant mu
LAMP5 lysosomal-associated membrane protein family, member 5
LTB lymphotoxin beta (TNF superfamily, member 3)
MGP matrix Gla protein
MSRB2 methionine sulfoxide reductase B2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDLIM3 PDZ and LIM domain 3
PRR15L proline rich 15-like
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA4 RAS p21 protein activator 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STK26 serine/threonine protein kinase 26
STMN1 stathmin 1
SULF1 sulfatase 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNS3 tensin 3
UBE2J1 ubiquitin-conjugating enzyme E2, J1
ZMIZ1 zinc finger, MIZ-type containing 1