BRD-K56515112_6alpha-methyl-11beta-hydroxyprogesterone_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K56515112_6alpha-methyl-11beta-hydroxyprogesterone_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
BIK BCL2-interacting killer (apoptosis-inducing)
C1S complement component 1, s subcomponent
CD59 CD59 molecule, complement regulatory protein
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
ECI2 enoyl-CoA delta isomerase 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EYA2 EYA transcriptional coactivator and phosphatase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FOXO3 forkhead box O3
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GOLGA4 golgin A4
GPER1 G protein-coupled estrogen receptor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HSPA2 heat shock 70kDa protein 2
INPP1 inositol polyphosphate-1-phosphatase
IRS2 insulin receptor substrate 2
KRT19 keratin 19, type I
LGMN legumain
LRRC16A leucine rich repeat containing 16A
MALT1 MALT1 paracaspase
MAPK6 mitogen-activated protein kinase 6
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP2 NLR family, pyrin domain containing 2
NNMT nicotinamide N-methyltransferase
OAT ornithine aminotransferase
OLFML2A olfactomedin-like 2A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGES prostaglandin E synthase
RAB9A RAB9A, member RAS oncogene family
RANBP9 RAN binding protein 9
RDX radixin
SCGB1D2 secretoglobin, family 1D, member 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPDEF SAM pointed domain containing ETS transcription factor
STK39 serine threonine kinase 39
SYBU syntabulin (syntaxin-interacting)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CD200 CD200 molecule
CX3CR1 chemokine (C-X3-C motif) receptor 1
DIAPH2 diaphanous-related formin 2
DLK1 delta-like 1 homolog (Drosophila)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F12 coagulation factor XII (Hageman factor)
GAL galanin/GMAP prepropeptide
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KCTD12 potassium channel tetramerization domain containing 12
LAMP5 lysosomal-associated membrane protein family, member 5
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MNDA myeloid cell nuclear differentiation antigen
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOLC1 nucleolar and coiled-body phosphoprotein 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PRR7 proline rich 7 (synaptic)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RNASE6 ribonuclease, RNase A family, k6
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SOX11 SRY (sex determining region Y)-box 11
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
ST7 suppression of tumorigenicity 7
VIM vimentin
WFDC1 WAP four-disulfide core domain 1