BRD-K56515112_6alpha-methyl-11beta-hydroxyprogesterone_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K56515112_6alpha-methyl-11beta-hydroxyprogesterone_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
C5AR1 complement component 5a receptor 1
CCNE2 cyclin E2
CD14 CD14 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDIT4 DNA-damage-inducible transcript 4
DIO1 deiodinase, iodothyronine, type I
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DSE dermatan sulfate epimerase
DSP desmoplakin
EMP1 epithelial membrane protein 1
FKBP5 FK506 binding protein 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FPR1 formyl peptide receptor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
LEPR leptin receptor
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGRN neugrin, neurite outgrowth associated
NRN1 neuritin 1
PDLIM1 PDZ and LIM domain 1
PER1 period circadian clock 1
PHACTR2 phosphatase and actin regulator 2
PRR15L proline rich 15-like
REEP5 receptor accessory protein 5
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RUFY3 RUN and FYVE domain containing 3
S100P S100 calcium binding protein P
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SNX11 sorting nexin 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
THBS1 thrombospondin 1
TSC22D3 TSC22 domain family, member 3
VCAN versican
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
APOD apolipoprotein D
BAX BCL2-associated X protein
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CLU clusterin
COCH cochlin
COL9A3 collagen, type IX, alpha 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DPYSL3 dihydropyrimidinase-like 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPM6A glycoprotein M6A
GSTM3 glutathione S-transferase mu 3 (brain)
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IL6 interleukin 6
KIF14 kinesin family member 14
LBH limb bud and heart development
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LYPD1 LY6/PLAUR domain containing 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MEIS1 Meis homeobox 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP10 matrix metallopeptidase 10
NES nestin
NR0B1 nuclear receptor subfamily 0, group B, member 1
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
RBP1 retinol binding protein 1, cellular
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
SCGB2A1 secretoglobin, family 2A, member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SSFA2 sperm specific antigen 2
STK32B serine/threonine kinase 32B
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TSPAN7 tetraspanin 7
VWA5A von Willebrand factor A domain containing 5A