BRD-K56411643_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K56411643_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLM glutamate-cysteine ligase, modifier subunit
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IL1R2 interleukin 1 receptor, type II
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KYNU kynureninase
LGALS2 lectin, galactoside-binding, soluble, 2
LOX lysyl oxidase
LPAR2 lysophosphatidic acid receptor 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1M metallothionein 1M
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPRED2 sprouty-related, EVH1 domain containing 2
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMD1 adenosylmethionine decarboxylase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
C8ORF4 chromosome 8 open reading frame 4
CCNE2 cyclin E2
CCNF cyclin F
EI24 etoposide induced 2.4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM107A family with sequence similarity 107, member A
FAM98A family with sequence similarity 98, member A
FHL1 four and a half LIM domains 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX1 glutathione peroxidase 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
LAPTM4B lysosomal protein transmembrane 4 beta
NFIB nuclear factor I/B
PRKCD protein kinase C, delta
SDC2 syndecan 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SOX4 SRY (sex determining region Y)-box 4
TARP TCR gamma alternate reading frame protein
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFBR3 transforming growth factor, beta receptor III
TSEN2 TSEN2 tRNA splicing endonuclease subunit