BRD-K56411643_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K56411643_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP8 aquaporin 8
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL6A3 collagen, type VI, alpha 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DUSP1 dual specificity phosphatase 1
FAIM Fas apoptotic inhibitory molecule
FHOD3 formin homology 2 domain containing 3
FMOD fibromodulin
GAS6 growth arrest-specific 6
GPNMB glycoprotein (transmembrane) nmb
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INSM1 insulinoma-associated 1
JUN jun proto-oncogene
KIAA0226L KIAA0226-like
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
MEIS2 Meis homeobox 2
MLPH melanophilin
MME membrane metallo-endopeptidase
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
PRKCI protein kinase C, iota
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
PTX3 pentraxin 3, long
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SQSTM1 sequestosome 1
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
STK38 serine/threonine kinase 38
SUSD4 sushi domain containing 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5B wingless-type MMTV integration site family, member 5B
WSB1 WD repeat and SOCS box containing 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
ATMIN ATM interactor
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CBFB core-binding factor, beta subunit
CD302 CD302 molecule
CDC42 cell division cycle 42
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFI complement factor I
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
DCK deoxycytidine kinase
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
EIF4E eukaryotic translation initiation factor 4E
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
GCH1 GTP cyclohydrolase 1
GMDS GDP-mannose 4,6-dehydratase
GRB14 growth factor receptor-bound protein 14
GSTT1 glutathione S-transferase theta 1
HLF hepatic leukemia factor
HOPX HOP homeobox
HOXC6 homeobox C6
IER3 immediate early response 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
LMO2 LIM domain only 2 (rhombotin-like 1)
MALL mal, T-cell differentiation protein-like
MARCKSL1 MARCKS-like 1
MGST2 microsomal glutathione S-transferase 2
MSL1 male-specific lethal 1 homolog (Drosophila)
MTTP microsomal triglyceride transfer protein
MTUS1 microtubule associated tumor suppressor 1
NOP16 NOP16 nucleolar protein
OXA1L oxidase (cytochrome c) assembly 1-like
PBK PDZ binding kinase
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
QDPR quinoid dihydropteridine reductase
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RRP1B ribosomal RNA processing 1B
RSL1D1 ribosomal L1 domain containing 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF6 serine/arginine-rich splicing factor 6
STOM stomatin
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRAPPC3 trafficking protein particle complex 3
TSPAN6 tetraspanin 6
UBE3C ubiquitin protein ligase E3C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)