BRD-K56343971_vemurafenib_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K56343971_vemurafenib_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP7 A kinase (PRKA) anchor protein 7
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD6 ankyrin repeat domain 6
ARMCX2 armadillo repeat containing, X-linked 2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CFI complement factor I
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
DAPK1 death-associated protein kinase 1
FBXO11 F-box protein 11
FGFR3 fibroblast growth factor receptor 3
FOXJ3 forkhead box J3
GALC galactosylceramidase
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2BD histone cluster 1, H2bd
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGF1 insulin-like growth factor 1 (somatomedin C)
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
LY75 lymphocyte antigen 75
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
PCSK1 proprotein convertase subtilisin/kexin type 1
PDZK1 PDZ domain containing 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCARD PYD and CARD domain containing
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SORBS2 sorbin and SH3 domain containing 2
SPON1 spondin 1, extracellular matrix protein
TMEM176B transmembrane protein 176B
TSPAN12 tetraspanin 12
WASL Wiskott-Aldrich syndrome-like
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAM28 ADAM metallopeptidase domain 28
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
CBR3 carbonyl reductase 3
CD9 CD9 molecule
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EREG epiregulin
FADS2 fatty acid desaturase 2
FADS3 fatty acid desaturase 3
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
H1F0 H1 histone family, member 0
HACD2 3-hydroxyacyl-CoA dehydratase 2
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT16 keratin 16, type I
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
ODC1 ornithine decarboxylase 1
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
POSTN periostin, osteoblast specific factor
PSCA prostate stem cell antigen
PTGER4 prostaglandin E receptor 4 (subtype EP4)
S100P S100 calcium binding protein P
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SGCE sarcoglycan, epsilon
SPRY2 sprouty homolog 2 (Drosophila)
SSBP2 single-stranded DNA binding protein 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)