BRD-K56343971_vemurafenib_MCF7_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K56343971_vemurafenib_MCF7_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALB albumin
APOE apolipoprotein E
ARID5B AT rich interactive domain 5B (MRF1-like)
AUTS2 autism susceptibility candidate 2
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CST1 cystatin SN
CTSB cathepsin B
DEPTOR DEP domain containing MTOR-interacting protein
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
EMX2 empty spiracles homeobox 2
EPHB2 EPH receptor B2
ERAP2 endoplasmic reticulum aminopeptidase 2
ESRRG estrogen-related receptor gamma
FOXO4 forkhead box O4
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST3H2A histone cluster 3, H2a
HOXC6 homeobox C6
HP haptoglobin
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIF5C kinesin family member 5C
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
NFE2L3 nuclear factor, erythroid 2-like 3
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCGF2 polycomb group ring finger 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLAGL1 pleiomorphic adenoma gene-like 1
PLSCR4 phospholipid scramblase 4
PRAME preferentially expressed antigen in melanoma
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
STAT5B signal transducer and activator of transcription 5B
SYT1 synaptotagmin I
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VSNL1 visinin-like 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AIF1 allograft inflammatory factor 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP3 aquaporin 3 (Gill blood group)
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCL5 chemokine (C-C motif) ligand 5
CD200 CD200 molecule
CD24 CD24 molecule
CKLF chemokine-like factor
CREB1 cAMP responsive element binding protein 1
CRIP2 cysteine-rich protein 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CTSG cathepsin G
DYNLT3 dynein, light chain, Tctex-type 3
ECM1 extracellular matrix protein 1
EFNB2 ephrin-B2
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1RN interleukin 1 receptor antagonist
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KAT6B K(lysine) acetyltransferase 6B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LST1 leukocyte specific transcript 1
LYZ lysozyme
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OLFML2A olfactomedin-like 2A
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PSIP1 PC4 and SFRS1 interacting protein 1
PXDN peroxidasin
RAD23B RAD23 homolog B (S. cerevisiae)
RPA3 replication protein A3, 14kDa
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SLC25A46 solute carrier family 25, member 46
SOX11 SRY (sex determining region Y)-box 11
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VEGFA vascular endothelial growth factor A