BRD-K56343971_vemurafenib_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-K56343971_vemurafenib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAT catalase
CCNG1 cyclin G1
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLIC5 chloride intracellular channel 5
DACH1 dachshund family transcription factor 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
EFNA1 ephrin-A1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM107A family with sequence similarity 107, member A
FAM63A family with sequence similarity 63, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR2 fibroblast growth factor receptor 2
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GABARAPL2 GABA(A) receptor-associated protein-like 2
GALC galactosylceramidase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS1 growth arrest-specific 1
GOLPH3L golgi phosphoprotein 3-like
GPC4 glypican 4
GPR137B G protein-coupled receptor 137B
GRAMD3 GRAM domain containing 3
GSN gelsolin
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST3H2A histone cluster 3, H2a
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPA2 heat shock 70kDa protein 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGBP1 immunoglobulin (CD79A) binding protein 1
IL1R1 interleukin 1 receptor, type I
INSIG2 insulin induced gene 2
ITM2C integral membrane protein 2C
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
MAGED1 melanoma antigen family D1
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MGST3 microsomal glutathione S-transferase 3
MME membrane metallo-endopeptidase
MSRB2 methionine sulfoxide reductase B2
MVP major vault protein
NMRK1 nicotinamide riboside kinase 1
NOV nephroblastoma overexpressed
NPC2 Niemann-Pick disease, type C2
OLFM4 olfactomedin 4
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBLD phenazine biosynthesis-like protein domain containing
PBX1 pre-B-cell leukemia homeobox 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PROM1 prominin 1
PROS1 protein S (alpha)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRK protein tyrosine phosphatase, receptor type, K
RAB13 RAB13, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
REG1A regenerating islet-derived 1 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E2B solute carrier family 35, member E2B
SLC44A4 solute carrier family 44, member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TM7SF2 transmembrane 7 superfamily member 2
TMC5 transmembrane channel-like 5
TMEM100 transmembrane protein 100
TMEM135 transmembrane protein 135
TMEM260 transmembrane protein 260
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
TTC3 tetratricopeptide repeat domain 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
YPEL5 yippee-like 5 (Drosophila)
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADORA2B adenosine A2b receptor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AMD1 adenosylmethionine decarboxylase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
AURKA aurora kinase A
BID BH3 interacting domain death agonist
BYSL bystin-like
CAPN2 calpain 2, (m/II) large subunit
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPU centromere protein U
CKLF chemokine-like factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCTPP1 dCTP pyrophosphatase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGR1 early growth response 1
FAM216A family with sequence similarity 216, member A
FGL2 fibrinogen-like 2
FOSL1 FOS-like antigen 1
FST follistatin
FXYD5 FXYD domain containing ion transport regulator 5
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HOXB2 homeobox B2
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
KIF20A kinesin family member 20A
LEF1 lymphoid enhancer-binding factor 1
LMNB2 lamin B2
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
RANBP1 RAN binding protein 1
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SMC3 structural maintenance of chromosomes 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SRM spermidine synthase
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TRBC1 T cell receptor beta constant 1
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)