BRD-K56343971_vemurafenib_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K56343971_vemurafenib_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARL4C ADP-ribosylation factor-like 4C
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNN3 calponin 3, acidic
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
EPHA3 EPH receptor A3
EPS8 epidermal growth factor receptor pathway substrate 8
FABP4 fatty acid binding protein 4, adipocyte
FGG fibrinogen gamma chain
FOXG1 forkhead box G1
GJA1 gap junction protein, alpha 1, 43kDa
IGFBP5 insulin-like growth factor binding protein 5
LMNA lamin A/C
MAP1B microtubule-associated protein 1B
PEG10 paternally expressed 10
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
SFRP1 secreted frizzled-related protein 1
SPP1 secreted phosphoprotein 1
TM4SF1 transmembrane 4 L six family member 1
TPBG trophoblast glycoprotein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADGRG6 adhesion G protein-coupled receptor G6
CALR calreticulin
CCL5 chemokine (C-C motif) ligand 5
CLDN3 claudin 3
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
ECM1 extracellular matrix protein 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
GCH1 GTP cyclohydrolase 1
H1F0 H1 histone family, member 0
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
NCF2 neutrophil cytosolic factor 2
NGRN neugrin, neurite outgrowth associated
PDGFRL platelet-derived growth factor receptor-like
PDLIM3 PDZ and LIM domain 3
PRUNE2 prune homolog 2 (Drosophila)
S100A12 S100 calcium binding protein A12
SAMD4A sterile alpha motif domain containing 4A
SFRP4 secreted frizzled-related protein 4
STXBP2 syntaxin binding protein 2
TARP TCR gamma alternate reading frame protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TSPYL5 TSPY-like 5
VAMP8 vesicle-associated membrane protein 8
ZBTB16 zinc finger and BTB domain containing 16