BRD-K56343971_PLX-4032_PL21_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K56343971_PLX-4032_PL21_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRF5 adhesion G protein-coupled receptor F5
AGTR1 angiotensin II receptor, type 1
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
APLP2 amyloid beta (A4) precursor-like protein 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BANK1 B-cell scaffold protein with ankyrin repeats 1
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGRRF1 cell growth regulator with ring finger domain 1
CLU clusterin
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
FAM129A family with sequence similarity 129, member A
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GALC galactosylceramidase
GATA6 GATA binding protein 6
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IL15 interleukin 15
ITGB5 integrin, beta 5
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KYNU kynureninase
LETMD1 LETM1 domain containing 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MNDA myeloid cell nuclear differentiation antigen
MT1G metallothionein 1G
MTSS1 metastasis suppressor 1
MYRF myelin regulatory factor
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PNRC1 proline-rich nuclear receptor coactivator 1
PRSS21 protease, serine, 21 (testisin)
PSPH phosphoserine phosphatase
RAB40B RAB40B, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SIDT2 SID1 transmembrane family, member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
STC2 stanniocalcin 2
TFRC transferrin receptor
TMPRSS3 transmembrane protease, serine 3
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WARS tryptophanyl-tRNA synthetase
WT1 Wilms tumor 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK2 AHNAK nucleoprotein 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA1 annexin A1
BASP1 brain abundant, membrane attached signal protein 1
C1ORF106 chromosome 1 open reading frame 106
CALR calreticulin
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH19 cadherin 19, type 2
CHI3L2 chitinase 3-like 2
CKAP4 cytoskeleton-associated protein 4
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
EBP emopamil binding protein (sterol isomerase)
EDN3 endothelin 3
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FHL1 four and a half LIM domains 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
ITM2C integral membrane protein 2C
KIAA0485 uncharacterized LOC57235
LAPTM4B lysosomal protein transmembrane 4 beta
LDHA lactate dehydrogenase A
MBOAT7 membrane bound O-acyltransferase domain containing 7
MFSD10 major facilitator superfamily domain containing 10
MREG melanoregulin
MSMO1 methylsterol monooxygenase 1
MTF2 metal response element binding transcription factor 2
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRMT1 protein arginine methyltransferase 1
RBMS1 RNA binding motif, single stranded interacting protein 1
S100B S100 calcium binding protein B
SDC1 syndecan 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TNC tenascin C
UBE2S ubiquitin-conjugating enzyme E2S
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF331 zinc finger protein 331