BRD-K56343971_PLX-4032_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K56343971_PLX-4032_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACADVL acyl-CoA dehydrogenase, very long chain
AMOTL2 angiomotin like 2
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATM ATM serine/threonine kinase
BACE2 beta-site APP-cleaving enzyme 2
C10ORF10 chromosome 10 open reading frame 10
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FN1 fibronectin 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8H golgin A8 family, member H
GUSBP11 glucuronidase, beta pseudogene 11
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HTRA1 HtrA serine peptidase 1
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
ITGB5 integrin, beta 5
LAMP3 lysosomal-associated membrane protein 3
NELL2 NEL-like 2 (chicken)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PPOX protoporphyrinogen oxidase
PTPRK protein tyrosine phosphatase, receptor type, K
RAP1GAP RAP1 GTPase activating protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SNX7 sorting nexin 7
STON1 stonin 1
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
CDC25A cell division cycle 25A
COMMD8 COMM domain containing 8
GLIPR1 GLI pathogenesis-related 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IDI1 isopentenyl-diphosphate delta isomerase 1
MALL mal, T-cell differentiation protein-like
MICB MHC class I polypeptide-related sequence B
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
SDC2 syndecan 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)