BRD-K56343971_HY-10247_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K56343971_HY-10247_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALAD aminolevulinate dehydratase
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
DARS aspartyl-tRNA synthetase
DEPTOR DEP domain containing MTOR-interacting protein
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
GOLGA8B golgin A8 family, member B
H1FX H1 histone family, member X
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H3H histone cluster 1, H3h
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IL6ST interleukin 6 signal transducer
IRX5 iroquois homeobox 5
KDM3A lysine (K)-specific demethylase 3A
LXN latexin
MAOB monoamine oxidase B
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBR1 neighbor of BRCA1 gene 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAD23B RAD23 homolog B (S. cerevisiae)
SH3YL1 SH3 and SYLF domain containing 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPATA20 spermatogenesis associated 20
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SVIL supervillin
TMEM123 transmembrane protein 123
TPD52 tumor protein D52
TXNIP thioredoxin interacting protein
VIM vimentin
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF5 activating transcription factor 5
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
C14ORF2 chromosome 14 open reading frame 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND3 cyclin D3
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CORO1A coronin, actin binding protein, 1A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFNB2 ephrin-B2
FGL2 fibrinogen-like 2
GALE UDP-galactose-4-epimerase
GLRX2 glutaredoxin 2
GPNMB glycoprotein (transmembrane) nmb
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPH1 heat shock 105kDa/110kDa protein 1
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
MAP2K3 mitogen-activated protein kinase kinase 3
MME membrane metallo-endopeptidase
PAK1IP1 PAK1 interacting protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPEN spen family transcriptional repressor
STK17A serine/threonine kinase 17a
ZW10 zw10 kinetochore protein