BRD-K56334280_S1367_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K56334280_S1367_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ANXA5 annexin A5
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BASP1 brain abundant, membrane attached signal protein 1
BCL3 B-cell CLL/lymphoma 3
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
CPVL carboxypeptidase, vitellogenic-like
CSNK2A2 casein kinase 2, alpha prime polypeptide
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EGR3 early growth response 3
ERAP2 endoplasmic reticulum aminopeptidase 2
FAS Fas cell surface death receptor
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FUCA1 fucosidase, alpha-L- 1, tissue
GATA2 GATA binding protein 2
GLIPR1 GLI pathogenesis-related 1
GSN gelsolin
GSTZ1 glutathione S-transferase zeta 1
HBEGF heparin-binding EGF-like growth factor
HOXA10 homeobox A10
HSBP1 heat shock factor binding protein 1
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT5 keratin 5, type II
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
MT1X metallothionein 1X
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBPF10 neuroblastoma breakpoint family, member 10
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
PEX11A peroxisomal biogenesis factor 11 alpha
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
S100A2 S100 calcium binding protein A2
SCPEP1 serine carboxypeptidase 1
SFN stratifin
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC44A4 solute carrier family 44, member 4
TIGAR TP53 induced glycolysis regulatory phosphatase
TMPRSS2 transmembrane protease, serine 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TRIAP1 TP53 regulated inhibitor of apoptosis 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
AMDHD2 amidohydrolase domain containing 2
ANGPT2 angiopoietin 2
CCNE2 cyclin E2
CD200 CD200 molecule
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CRABP1 cellular retinoic acid binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
DHCR7 7-dehydrocholesterol reductase
DMBT1 deleted in malignant brain tumors 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP7 fatty acid binding protein 7, brain
FAM57A family with sequence similarity 57, member A
FGFR2 fibroblast growth factor receptor 2
FOXM1 forkhead box M1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRWD1 glutamate-rich WD repeat containing 1
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
LPCAT1 lysophosphatidylcholine acyltransferase 1
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MZB1 marginal zone B and B1 cell-specific protein
NCAPG non-SMC condensin I complex, subunit G
NME4 NME/NM23 nucleoside diphosphate kinase 4
NXN nucleoredoxin
ORC1 origin recognition complex, subunit 1
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G16 phospholipase A2, group XVI
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PRODH proline dehydrogenase (oxidase) 1
RGCC regulator of cell cycle
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SDC1 syndecan 1
SDF2L1 stromal cell-derived factor 2-like 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
UBE2C ubiquitin-conjugating enzyme E2C
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VCAM1 vascular cell adhesion molecule 1
VGLL1 vestigial-like family member 1