BRD-K56277358_MGCD-265_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K56277358_MGCD-265_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
ASNS asparagine synthetase (glutamine-hydrolyzing)
BASP1 brain abundant, membrane attached signal protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
CBS cystathionine-beta-synthase
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DENND2D DENN/MADD domain containing 2D
DHCR24 24-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GREM1 gremlin 1, DAN family BMP antagonist
HCAR3 hydroxycarboxylic acid receptor 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT14 keratin 14, type I
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LY75 lymphocyte antigen 75
LYZ lysozyme
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
PHGDH phosphoglycerate dehydrogenase
PPL periplakin
QPCT glutaminyl-peptide cyclotransferase
RGS4 regulator of G-protein signaling 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SPAG4 sperm associated antigen 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC2 stanniocalcin 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM29 tripartite motif containing 29
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANO1 anoctamin 1, calcium activated chloride channel
ASRGL1 asparaginase like 1
AUTS2 autism susceptibility candidate 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CTSH cathepsin H
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EMX2 empty spiracles homeobox 2
FAM107A family with sequence similarity 107, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
GSTT1 glutathione S-transferase theta 1
HTRA1 HtrA serine peptidase 1
LHX2 LIM homeobox 2
MAOB monoamine oxidase B
MFAP2 microfibrillar-associated protein 2
MGP matrix Gla protein
NFIB nuclear factor I/B
PBX1 pre-B-cell leukemia homeobox 1
PDZK1 PDZ domain containing 1
PEG3 paternally expressed 3
PHACTR2 phosphatase and actin regulator 2
SEC16A SEC16 homolog A (S. cerevisiae)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
ZIC1 Zic family member 1
ZNF589 zinc finger protein 589