BRD-K56277358_MGCD-265_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K56277358_MGCD-265_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
APOE apolipoprotein E
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZW2 basic leucine zipper and W2 domains 2
C5 complement component 5
CALML4 calmodulin-like 4
CBR3 carbonyl reductase 3
CD302 CD302 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHPT1 choline phosphotransferase 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
FCGBP Fc fragment of IgG binding protein
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GLRX glutaredoxin (thioltransferase)
HLA-DMA major histocompatibility complex, class II, DM alpha
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
LPAR2 lysophosphatidic acid receptor 2
LPIN2 lipin 2
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NR1H2 nuclear receptor subfamily 1, group H, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHGDH phosphoglycerate dehydrogenase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SQSTM1 sequestosome 1
TFF3 trefoil factor 3 (intestinal)
TSC22D1 TSC22 domain family, member 1

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ANXA3 annexin A3
AUTS2 autism susceptibility candidate 2
CAV1 caveolin 1, caveolae protein, 22kDa
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
FRZB frizzled-related protein
HIST1H4C histone cluster 1, H4c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IRF8 interferon regulatory factor 8
KRT17 keratin 17, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100505650 uncharacterized LOC100505650
LYPD1 LY6/PLAUR domain containing 1
MMP7 matrix metallopeptidase 7
MXRA7 matrix-remodelling associated 7
NPTX2 neuronal pentraxin II
PARP2 poly (ADP-ribose) polymerase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RCAN2 regulator of calcineurin 2
TCF4 transcription factor 4