BRD-K56277358_MGCD-265_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K56277358_MGCD-265_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BASP1 brain abundant, membrane attached signal protein 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C7 complement component 7
CBS cystathionine-beta-synthase
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CTSS cathepsin S
DDIT4 DNA-damage-inducible transcript 4
DSE dermatan sulfate epimerase
ELOVL6 ELOVL fatty acid elongase 6
FAM129A family with sequence similarity 129, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GPX2 glutathione peroxidase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HSPA12A heat shock 70kDa protein 12A
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IL1R2 interleukin 1 receptor, type II
JCHAIN joining chain of multimeric IgA and IgM
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LRP10 low density lipoprotein receptor-related protein 10
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NEFL neurofilament, light polypeptide
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
PAEP progestagen-associated endometrial protein
PSAT1 phosphoserine aminotransferase 1
QPCT glutaminyl-peptide cyclotransferase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SIRT3 sirtuin 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TRAF5 TNF receptor-associated factor 5
VNN1 vanin 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CXADR coxsackie virus and adenovirus receptor
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
GNAS GNAS complex locus
H2AFX H2A histone family, member X
HIST1H1C histone cluster 1, H1c
HMGB2 high mobility group box 2
KIF20A kinesin family member 20A
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNB1 lamin B1
MGP matrix Gla protein
NRCAM neuronal cell adhesion molecule
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PODXL podocalyxin-like
RHOB ras homolog family member B
RPA1 replication protein A1, 70kDa
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SRI sorcin
SRRM1 serine/arginine repetitive matrix 1
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TMSB15A thymosin beta 15a