BRD-K56277358_MGCD-265_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K56277358_MGCD-265_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DSG2 desmoglein 2
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
FAM65B family with sequence similarity 65, member B
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGG fibrinogen gamma chain
GPC3 glypican 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INSIG1 insulin induced gene 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NMU neuromedin U
NSDHL NAD(P) dependent steroid dehydrogenase-like
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCP4 Purkinje cell protein 4
PHGDH phosphoglycerate dehydrogenase
PTN pleiotrophin
QKI QKI, KH domain containing, RNA binding
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SIRT3 sirtuin 3
SOX11 SRY (sex determining region Y)-box 11
SQLE squalene epoxidase
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TXNIP thioredoxin interacting protein
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BASP1 brain abundant, membrane attached signal protein 1
BZW2 basic leucine zipper and W2 domains 2
CXCL5 chemokine (C-X-C motif) ligand 5
F3 coagulation factor III (thromboplastin, tissue factor)
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GATA3 GATA binding protein 3
HOPX HOP homeobox
IGFBP4 insulin-like growth factor binding protein 4
IRS1 insulin receptor substrate 1
LAMB1 laminin, beta 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PODXL podocalyxin-like
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PYCARD PYD and CARD domain containing
REG1A regenerating islet-derived 1 alpha
S100A9 S100 calcium binding protein A9
SFRP1 secreted frizzled-related protein 1
SRRM2 serine/arginine repetitive matrix 2
STC1 stanniocalcin 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TSPAN5 tetraspanin 5
UBE3C ubiquitin protein ligase E3C