BRD-K56196992_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

246 genes differentially expressed following the BRD-K56196992_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM19 ADAM metallopeptidase domain 19
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG6 adhesion G protein-coupled receptor G6
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
AREG amphiregulin
AVPI1 arginine vasopressin-induced 1
BLVRA biliverdin reductase A
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL5 chemokine (C-C motif) ligand 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLIC3 chloride intracellular channel 3
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
CTSB cathepsin B
CTSL cathepsin L
CTSV cathepsin V
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
DUOX2 dual oxidase 2
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENAH enabled homolog (Drosophila)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FAM49A family with sequence similarity 49, member A
FDX1 ferredoxin 1
FN1 fibronectin 1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD5 frizzled class receptor 5
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALC galactosylceramidase
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNS glucosamine (N-acetyl)-6-sulfatase
GPR137B G protein-coupled receptor 137B
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HEPH hephaestin
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KLF10 Kruppel-like factor 10
LBH limb bud and heart development
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL2 lysyl oxidase-like 2
LYZ lysozyme
MAOA monoamine oxidase A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MOSPD1 motile sperm domain containing 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NTS neurotensin
OLFM4 olfactomedin 4
PAM peptidylglycine alpha-amidating monooxygenase
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG3 paternally expressed 3
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLS1 plastin 1
PPAP2A phosphatidic acid phosphatase type 2A
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRUNE2 prune homolog 2 (Drosophila)
PYGL phosphorylase, glycogen, liver
QPCT glutaminyl-peptide cyclotransferase
RAB29 RAB29, member RAS oncogene family
RASL11B RAS-like, family 11, member B
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RIMS3 regulating synaptic membrane exocytosis 3
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAS related RAS viral (r-ras) oncogene homolog
S100A10 S100 calcium binding protein A10
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SERINC5 serine incorporator 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STON1 stonin 1
SYT1 synaptotagmin I
TCEAL2 transcription elongation factor A (SII)-like 2
TM4SF20 transmembrane 4 L six family member 20
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TSPAN5 tetraspanin 5
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
VIM vimentin
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AMDHD2 amidohydrolase domain containing 2
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF5 activating transcription factor 5
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
C20ORF27 chromosome 20 open reading frame 27
CCDC85B coiled-coil domain containing 85B
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CLU clusterin
CRCT1 cysteine-rich C-terminal 1
CSK c-src tyrosine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKC1 dyskeratosis congenita 1, dyskerin
DPH2 DPH2 homolog (S. cerevisiae)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FEN1 flap structure-specific endonuclease 1
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
IL17RB interleukin 17 receptor B
IL1RN interleukin 1 receptor antagonist
IPO4 importin 4
IRAK1 interleukin-1 receptor-associated kinase 1
KDM5D lysine (K)-specific demethylase 5D
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MAB21L1 mab-21-like 1 (C. elegans)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPS30 mitochondrial ribosomal protein S30
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT10 N-acetyltransferase 10 (GCN5-related)
NFIB nuclear factor I/B
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NUP88 nucleoporin 88kDa
OXTR oxytocin receptor
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRMT1 protein arginine methyltransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB5C RAB5C, member RAS oncogene family
RELN reelin
RFC2 replication factor C (activator 1) 2, 40kDa
RGS5 regulator of G-protein signaling 5
RNASEH2A ribonuclease H2, subunit A
RNF167 ring finger protein 167
RPA3 replication protein A3, 14kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC35B1 solute carrier family 35, member B1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPDEF SAM pointed domain containing ETS transcription factor
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TP53 tumor protein p53
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
XBP1 X-box binding protein 1