BRD-K55844427_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K55844427_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CAPN2 calpain 2, (m/II) large subunit
CCL20 chemokine (C-C motif) ligand 20
CD9 CD9 molecule
CDC42 cell division cycle 42
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFB complement factor B
CHD7 chromodomain helicase DNA binding protein 7
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CST6 cystatin E/M
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IGKC immunoglobulin kappa constant
IL32 interleukin 32
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LTBP3 latent transforming growth factor beta binding protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
NAMPT nicotinamide phosphoribosyltransferase
NEFL neurofilament, light polypeptide
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLAT plasminogen activator, tissue
PMEPA1 prostate transmembrane protein, androgen induced 1
QKI QKI, KH domain containing, RNA binding
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC4 syndecan 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
TACC2 transforming, acidic coiled-coil containing protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
ZFP36L1 ZFP36 ring finger protein-like 1
ZYX zyxin

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRL4 adhesion G protein-coupled receptor L4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
CD38 CD38 molecule
CDC20 cell division cycle 20
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CECR1 cat eye syndrome chromosome region, candidate 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL3A1 collagen, type III, alpha 1
COMMD8 COMM domain containing 8
DPYD dihydropyrimidine dehydrogenase
E2F2 E2F transcription factor 2
EFHD1 EF-hand domain family, member D1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR3 fibroblast growth factor receptor 3
GNAS GNAS complex locus
GRB7 growth factor receptor-bound protein 7
HDDC2 HD domain containing 2
HLF hepatic leukemia factor
HMGN3 high mobility group nucleosomal binding domain 3
HNMT histamine N-methyltransferase
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
NID2 nidogen 2 (osteonidogen)
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PLAC8 placenta-specific 8
PMM2 phosphomannomutase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RAD51C RAD51 paralog C
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
TMSB15A thymosin beta 15a
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZDHHC11 zinc finger, DHHC-type containing 11
ZWINT ZW10 interacting kinetochore protein