BRD-K55844427_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K55844427_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BET1 Bet1 golgi vesicular membrane trafficking protein
BHLHE40 basic helix-loop-helix family, member e40
CD24 CD24 molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CHIC2 cysteine-rich hydrophobic domain 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSC cathepsin C
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EAPP E2F-associated phosphoprotein
EGR1 early growth response 1
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IGKV4-1 immunoglobulin kappa variable 4-1
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUCB2 nucleobindin 2
PLAU plasminogen activator, urokinase
SARAF store-operated calcium entry-associated regulatory factor
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFTPB surfactant protein B
SKAP2 src kinase associated phosphoprotein 2
SRGN serglycin
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSPYL2 TSPY-like 2
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ANGPT1 angiopoietin 1
CALB1 calbindin 1, 28kDa
CANT1 calcium activated nucleotidase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CTNND1 catenin (cadherin-associated protein), delta 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
ITGA6 integrin, alpha 6
LAMA4 laminin, alpha 4
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRN3 leucine rich repeat neuronal 3
MFAP2 microfibrillar-associated protein 2
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MYBPC1 myosin binding protein C, slow type
NIT1 nitrilase 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC8 placenta-specific 8
PNISR PNN-interacting serine/arginine-rich protein
RTN2 reticulon 2
RUNX1 runt-related transcription factor 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR3 small proline-rich protein 3
TMPRSS2 transmembrane protease, serine 2