BRD-K55827386_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K55827386_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACPP acid phosphatase, prostate
AIDA axin interactor, dorsalization associated
ALOX5 arachidonate 5-lipoxygenase
C10ORF10 chromosome 10 open reading frame 10
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CLEC5A C-type lectin domain family 5, member A
COL1A2 collagen, type I, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBB cytochrome b-245, beta polypeptide
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FGR FGR proto-oncogene, Src family tyrosine kinase
FILIP1L filamin A interacting protein 1-like
FRY furry homolog (Drosophila)
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HAPLN1 hyaluronan and proteoglycan link protein 1
HEBP2 heme binding protein 2
IL13RA1 interleukin 13 receptor, alpha 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
LMO3 LIM domain only 3 (rhombotin-like 2)
LTA4H leukotriene A4 hydrolase
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK5 proprotein convertase subtilisin/kexin type 5
PDE4B phosphodiesterase 4B, cAMP-specific
PELI1 pellino E3 ubiquitin protein ligase 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRR15L proline rich 15-like
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
PTPRF protein tyrosine phosphatase, receptor type, F
RGCC regulator of cell cycle
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STS steroid sulfatase (microsomal), isozyme S
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TESK1 testis-specific kinase 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
TYMP thymidine phosphorylase
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VSIG4 V-set and immunoglobulin domain containing 4
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BASP1 brain abundant, membrane attached signal protein 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
BTBD3 BTB (POZ) domain containing 3
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CLU clusterin
CRISP3 cysteine-rich secretory protein 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DUSP5 dual specificity phosphatase 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM46A family with sequence similarity 46, member A
FZD7 frizzled class receptor 7
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRWD1 glutamate-rich WD repeat containing 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGKV4-1 immunoglobulin kappa variable 4-1
JARID2 jumonji, AT rich interactive domain 2
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
MSL2 male-specific lethal 2 homolog (Drosophila)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPY1R neuropeptide Y receptor Y1
NUP98 nucleoporin 98kDa
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1 PDZ domain containing 1
PLAC8 placenta-specific 8
PROM1 prominin 1
PRR4 proline rich 4 (lacrimal)
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
SATB1 SATB homeobox 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIK1 salt-inducible kinase 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO1B3 solute carrier organic anion transporter family, member 1B3
TATDN2 TatD DNase domain containing 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM185B transmembrane protein 185B
TRIM44 tripartite motif containing 44
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8