BRD-K55722623_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K55722623_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BLVRB biliverdin reductase B
CA2 carbonic anhydrase II
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CKB creatine kinase, brain
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IL1R2 interleukin 1 receptor, type II
IL6R interleukin 6 receptor
JMJD6 jumonji domain containing 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSRB1 methionine sulfoxide reductase B1
MT1M metallothionein 1M
NEU1 sialidase 1 (lysosomal sialidase)
NQO2 NAD(P)H dehydrogenase, quinone 2
NXN nucleoredoxin
ODC1 ornithine decarboxylase 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPN12 protein tyrosine phosphatase, non-receptor type 12
SCGB2A1 secretoglobin, family 2A, member 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
TGFBI transforming growth factor, beta-induced, 68kDa
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TUBB2A tubulin, beta 2A class IIa
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WAC WW domain containing adaptor with coiled-coil
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
APOE apolipoprotein E
B3GNT1
BIRC3 baculoviral IAP repeat containing 3
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNF cyclin F
CD24 CD24 molecule
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DLG5 discs, large homolog 5 (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HOPX HOP homeobox
HOXA5 homeobox A5
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IL1RN interleukin 1 receptor antagonist
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KRT7 keratin 7, type II
LRRN3 leucine rich repeat neuronal 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MREG melanoregulin
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
PCNA proliferating cell nuclear antigen
PDE1A phosphodiesterase 1A, calmodulin-dependent
POSTN periostin, osteoblast specific factor
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
SOX4 SRY (sex determining region Y)-box 4
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TKTL1 transketolase-like 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TSC22D1 TSC22 domain family, member 1
TYMS thymidylate synthetase