BRD-K55722623_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K55722623_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
COL9A2 collagen, type IX, alpha 2
DCN decorin
DEGS1 delta(4)-desaturase, sphingolipid 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EIF1 eukaryotic translation initiation factor 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PEG3 paternally expressed 3
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
THBS2 thrombospondin 2
TXNRD1 thioredoxin reductase 1
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD24 CD24 molecule
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYB561 cytochrome b561
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MCUR1 mitochondrial calcium uniporter regulator 1
PDZK1 PDZ domain containing 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLK1 polo-like kinase 1
PRSS23 protease, serine, 23
RPL36 ribosomal protein L36
RPN2 ribophorin II
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TXNL4A thioredoxin-like 4A
XPO7 exportin 7