BRD-K55612480_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

365 genes differentially expressed following the BRD-K55612480_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACLY ATP citrate lyase
ADA adenosine deaminase
ADM adrenomedullin
AHCYL1 adenosylhomocysteinase-like 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALAS2 5'-aminolevulinate synthase 2
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ARHGAP29 Rho GTPase activating protein 29
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAPG capping protein (actin filament), gelsolin-like
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CKB creatine kinase, brain
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
CRIP2 cysteine-rich protein 2
CSF1R colony stimulating factor 1 receptor
CSRP2 cysteine and glycine-rich protein 2
CTSB cathepsin B
CTSL cathepsin L
CYB5A cytochrome b5 type A (microsomal)
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMXL2 Dmx-like 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FADS1 fatty acid desaturase 1
FAM107A family with sequence similarity 107, member A
FAM117A family with sequence similarity 117, member A
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GAGE3 G antigen 3
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR137B G protein-coupled receptor 137B
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IFI30 interferon, gamma-inducible protein 30
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
INSIG1 insulin induced gene 1
INSR insulin receptor
ITM2C integral membrane protein 2C
KLHL24 kelch-like family member 24
LCK LCK proto-oncogene, Src family tyrosine kinase
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MCOLN1 mucolipin 1
MFAP2 microfibrillar-associated protein 2
MGST3 microsomal glutathione S-transferase 3
MT1X metallothionein 1X
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NBPF10 neuroblastoma breakpoint family, member 10
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH17 protocadherin 17
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEG10 paternally expressed 10
PLIN2 perilipin 2
POR P450 (cytochrome) oxidoreductase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKD3 protein kinase D3
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RAB29 RAB29, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RBP4 retinol binding protein 4, plasma
RGS16 regulator of G-protein signaling 16
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFXN3 sideroflexin 3
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC22A18 solute carrier family 22, member 18
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNN stannin
SOX2 SRY (sex determining region Y)-box 2
SQSTM1 sequestosome 1
SST somatostatin
STC1 stanniocalcin 1
STOM stomatin
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFE3 transcription factor binding to IGHM enhancer 3
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VIM vimentin
VNN1 vanin 1
WLS wntless Wnt ligand secretion mediator
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AGR2 anterior gradient 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA7 annexin A7
ATF5 activating transcription factor 5
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CA12 carbonic anhydrase XII
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CFH complement factor H
CHEK2 checkpoint kinase 2
CKAP4 cytoskeleton-associated protein 4
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CRTAP cartilage associated protein
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEPTOR DEP domain containing MTOR-interacting protein
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPH2 DPH2 homolog (S. cerevisiae)
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
ESRP2 epithelial splicing regulatory protein 2
EXOSC8 exosome component 8
FAM57A family with sequence similarity 57, member A
FAM63A family with sequence similarity 63, member A
FANCI Fanconi anemia, complementation group I
FHL2 four and a half LIM domains 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXM1 forkhead box M1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1RAP interleukin 1 receptor accessory protein
IL20RA interleukin 20 receptor, alpha
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KLK11 kallikrein-related peptidase 11
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MGST2 microsomal glutathione S-transferase 2
MLPH melanophilin
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPL23 mitochondrial ribosomal protein L23
MRPL3 mitochondrial ribosomal protein L3
MRPS16 mitochondrial ribosomal protein S16
MRPS30 mitochondrial ribosomal protein S30
MRPS35 mitochondrial ribosomal protein S35
MSMB microseminoprotein, beta-
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP88 nucleoporin 88kDa
NXT1 nuclear transport factor 2-like export factor 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PALMD palmdelphin
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POSTN periostin, osteoblast specific factor
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRSS23 protease, serine, 23
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB25 RAB25, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEH1L SEH1-like (S. cerevisiae)
SFPQ splicing factor proline/glutamine-rich
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SRM spermidine synthase
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TLK1 tousled-like kinase 1
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRIM22 tripartite motif containing 22
TRIP13 thyroid hormone receptor interactor 13
TTC19 tetratricopeptide repeat domain 19
TXNDC15 thioredoxin domain containing 15
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XBP1 X-box binding protein 1
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein