BRD-K55187425_ON-01910_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

253 genes differentially expressed following the BRD-K55187425_ON-01910_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
ADGRA3 adhesion G protein-coupled receptor A3
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
AOC3 amine oxidase, copper containing 3
APOLD1 apolipoprotein L domain containing 1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARL4A ADP-ribosylation factor-like 4A
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG2 BCL2-associated athanogene 2
BHLHE40 basic helix-loop-helix family, member e40
BMP5 bone morphogenetic protein 5
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CERS6 ceramide synthase 6
CFD complement factor D (adipsin)
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC3 chloride intracellular channel 3
CLTB clathrin, light chain B
COCH cochlin
COL18A1 collagen, type XVIII, alpha 1
COLEC12 collectin sub-family member 12
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP1 cysteine and glycine-rich protein 1
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
CTSL cathepsin L
CYR61 cysteine-rich, angiogenic inducer, 61
DAXX death-domain associated protein
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
G0S2 G0/G1 switch 2
GAS2L1 growth arrest-specific 2 like 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GPR171 G protein-coupled receptor 171
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCAR3 hydroxycarboxylic acid receptor 3
HN1 hematological and neurological expressed 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IFRD1 interferon-related developmental regulator 1
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
INHBB inhibin, beta B
IRAK1 interleukin-1 receptor-associated kinase 1
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
KLF9 Kruppel-like factor 9
KYNU kynureninase
LAMP1 lysosomal-associated membrane protein 1
LGALS4 lectin, galactoside-binding, soluble, 4
LPL lipoprotein lipase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOB monoamine oxidase B
METRN meteorin, glial cell differentiation regulator
MMP9 matrix metallopeptidase 9
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MYO1B myosin IB
NADK NAD kinase
NMU neuromedin U
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PALLD palladin, cytoskeletal associated protein
PALMD palmdelphin
PAWR PRKC, apoptosis, WT1, regulator
PDLIM5 PDZ and LIM domain 5
PECR peroxisomal trans-2-enoyl-CoA reductase
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PODXL podocalyxin-like
PRR7 proline rich 7 (synaptic)
PTRF polymerase I and transcript release factor
RAD50 RAD50 homolog (S. cerevisiae)
RBP4 retinol binding protein 4, plasma
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A7 S100 calcium binding protein A7
SDC2 syndecan 2
SDC3 syndecan 3
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SH2D2A SH2 domain containing 2A
SLA Src-like-adaptor
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD3 SMAD family member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
TARP TCR gamma alternate reading frame protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBC1D4 TBC1 domain family, member 4
TCF3 transcription factor 3
TCL1A T-cell leukemia/lymphoma 1A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TRAC T cell receptor alpha constant
TRD T cell receptor delta locus
TRPS1 trichorhinophalangeal syndrome I
USP22 ubiquitin specific peptidase 22
VDAC1 voltage-dependent anion channel 1
WDR7 WD repeat domain 7
WSB2 WD repeat and SOCS box containing 2
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AFF1 AF4/FMR2 family, member 1
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BASP1 brain abundant, membrane attached signal protein 1
CADM1 cell adhesion molecule 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAPN3 calpain 3, (p94)
CCNE2 cyclin E2
CD58 CD58 molecule
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CGRRF1 cell growth regulator with ring finger domain 1
CHEK2 checkpoint kinase 2
CHMP5 charged multivesicular body protein 5
CLDND1 claudin domain containing 1
CLTA clathrin, light chain A
CRYL1 crystallin, lambda 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
FANCG Fanconi anemia, complementation group G
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FXYD3 FXYD domain containing ion transport regulator 3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS7 growth arrest-specific 7
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLS glutaminase
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRHPR glyoxylate reductase/hydroxypyruvate reductase
GTPBP8 GTP-binding protein 8 (putative)
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXD1 homeobox D1
HPN hepsin
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
IL6 interleukin 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0101 KIAA0101
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
MAGED1 melanoma antigen family D1
MAPT microtubule-associated protein tau
MBP myelin basic protein
MDK midkine (neurite growth-promoting factor 2)
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MSLN mesothelin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTMR11 myotubularin related protein 11
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NET1 neuroepithelial cell transforming 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCBP2 poly(rC) binding protein 2
PCNA proliferating cell nuclear antigen
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMM1 phosphomannomutase 1
PRKCD protein kinase C, delta
PRR15L proline rich 15-like
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD51AP1 RAD51 associated protein 1
RNASE4 ribonuclease, RNase A family, 4
RNF38 ring finger protein 38
RRM2 ribonucleotide reductase M2
SKP1 S-phase kinase-associated protein 1
SMAD1 SMAD family member 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM243 transmembrane protein 243, mitochondrial
TMEM87A transmembrane protein 87A
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VLDLR very low density lipoprotein receptor
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1