BRD-K55187425_ON-01910_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K55187425_ON-01910_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
AREG amphiregulin
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
COL4A5 collagen, type IV, alpha 5
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DLK1 delta-like 1 homolog (Drosophila)
EGR1 early growth response 1
EHD4 EH-domain containing 4
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GRB10 growth factor receptor-bound protein 10
IER3 immediate early response 3
ISOC1 isochorismatase domain containing 1
ITGA6 integrin, alpha 6
JAG1 jagged 1
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAST2 microtubule associated serine/threonine kinase 2
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MSN moesin
NPTX2 neuronal pentraxin II
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PODXL podocalyxin-like
RBP1 retinol binding protein 1, cellular
RPS27L ribosomal protein S27-like
S100A2 S100 calcium binding protein A2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SOX4 SRY (sex determining region Y)-box 4
STAR steroidogenic acute regulatory protein
TAGLN transgelin
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
VNN1 vanin 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANG angiogenin, ribonuclease, RNase A family, 5
ATP9A ATPase, class II, type 9A
C1S complement component 1, s subcomponent
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHEK2 checkpoint kinase 2
CLU clusterin
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DPP4 dipeptidyl-peptidase 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
FASN fatty acid synthase
FGB fibrinogen beta chain
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCA grancalcin, EF-hand calcium binding protein
HBB hemoglobin, beta
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
IFI44L interferon-induced protein 44-like
IL1R1 interleukin 1 receptor, type I
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEOX1 mesenchyme homeobox 1
MMD monocyte to macrophage differentiation-associated
MPC2 mitochondrial pyruvate carrier 2
MPO myeloperoxidase
MXRA5 matrix-remodelling associated 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDE4B phosphodiesterase 4B, cAMP-specific
PECR peroxisomal trans-2-enoyl-CoA reductase
PGM1 phosphoglucomutase 1
PON3 paraoxonase 3
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFC3 replication factor C (activator 1) 3, 38kDa
RNASE4 ribonuclease, RNase A family, 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINK5 serine peptidase inhibitor, Kazal type 5
SQLE squalene epoxidase
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
ZSCAN18 zinc finger and SCAN domain containing 18
ZWINT ZW10 interacting kinetochore protein