BRD-K55127335_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K55127335_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAPG capping protein (actin filament), gelsolin-like
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKM creatine kinase, muscle
COL8A2 collagen, type VIII, alpha 2
COL9A2 collagen, type IX, alpha 2
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
EPN2 epsin 2
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FST follistatin
GSDMB gasdermin B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP12 matrix metallopeptidase 12
NEB nebulin
PDLIM3 PDZ and LIM domain 3
PERP PERP, TP53 apoptosis effector
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC38A1 solute carrier family 38, member 1
SOX9 SRY (sex determining region Y)-box 9
SPON2 spondin 2, extracellular matrix protein
SSPN sarcospan
SULF1 sulfatase 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TTN titin
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AHCY adenosylhomocysteinase
APOD apolipoprotein D
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK4 cyclin-dependent kinase 4
CPD carboxypeptidase D
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
GLDC glycine dehydrogenase (decarboxylating)
HOXA5 homeobox A5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF5C kinesin family member 5C
LAMP1 lysosomal-associated membrane protein 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MSH6 mutS homolog 6
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC2 Niemann-Pick disease, type C2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
SFRP1 secreted frizzled-related protein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TXNDC9 thioredoxin domain containing 9
VCAM1 vascular cell adhesion molecule 1