BRD-K55127134_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K55127134_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAT2 acetyl-CoA acetyltransferase 2
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOC aldolase C, fructose-bisphosphate
ANO10 anoctamin 10
ANXA3 annexin A3
AREG amphiregulin
BACE2 beta-site APP-cleaving enzyme 2
CCNG2 cyclin G2
CD47 CD47 molecule
CFB complement factor B
CST3 cystatin C
CYBRD1 cytochrome b reductase 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
FADS1 fatty acid desaturase 1
FBN2 fibrillin 2
FBP1 fructose-1,6-bisphosphatase 1
FDPS farnesyl diphosphate synthase
FHL2 four and a half LIM domains 2
FST follistatin
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FZD7 frizzled class receptor 7
GAA glucosidase, alpha; acid
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS6 growth arrest-specific 6
GNPDA1 glucosamine-6-phosphate deaminase 1
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTBP1 latent transforming growth factor beta binding protein 1
MDK midkine (neurite growth-promoting factor 2)
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MYB v-myb avian myeloblastosis viral oncogene homolog
NPC2 Niemann-Pick disease, type C2
PDGFC platelet derived growth factor C
PDLIM1 PDZ and LIM domain 1
PGLS 6-phosphogluconolactonase
PLK2 polo-like kinase 2
PTX3 pentraxin 3, long
PYGL phosphorylase, glycogen, liver
QPRT quinolinate phosphoribosyltransferase
RAP1GAP RAP1 GTPase activating protein
RHOB ras homolog family member B
RHOBTB1 Rho-related BTB domain containing 1
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMYD3 SET and MYND domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STXBP1 syntaxin binding protein 1
TFF3 trefoil factor 3 (intestinal)
TIMP1 TIMP metallopeptidase inhibitor 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
VGLL4 vestigial-like family member 4
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CALD1 caldesmon 1
CCNA2 cyclin A2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBP1 guanylate binding protein 1, interferon-inducible
GTSE1 G-2 and S-phase expressed 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
HSPH1 heat shock 105kDa/110kDa protein 1
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LMO3 LIM domain only 3 (rhombotin-like 2)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
NLRP2 NLR family, pyrin domain containing 2
PLK1 polo-like kinase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGCC regulator of cell cycle
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TCF4 transcription factor 4
TMEM47 transmembrane protein 47
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
XPO7 exportin 7
ZNF395 zinc finger protein 395