BRD-K55116708_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K55116708_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ALOX15B arachidonate 15-lipoxygenase, type B
APOC1 apolipoprotein C-I
ARG2 arginase 2
ARID5B AT rich interactive domain 5B (MRF1-like)
C10ORF10 chromosome 10 open reading frame 10
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CLASRP CLK4-associating serine/arginine rich protein
CLDN3 claudin 3
CLPTM1 cleft lip and palate associated transmembrane protein 1
COCH cochlin
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL9A2 collagen, type IX, alpha 2
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DLK1 delta-like 1 homolog (Drosophila)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELOVL5 ELOVL fatty acid elongase 5
ENO1 enolase 1, (alpha)
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
GANAB glucosidase, alpha; neutral AB
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IL32 interleukin 32
KLK3 kallikrein-related peptidase 3
LEF1 lymphoid enhancer-binding factor 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LTB lymphotoxin beta (TNF superfamily, member 3)
LXN latexin
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTSS1 metastasis suppressor 1
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PRAME preferentially expressed antigen in melanoma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS10 regulator of G-protein signaling 10
RNF167 ring finger protein 167
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM259 transmembrane protein 259
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
VAV3 vav 3 guanine nucleotide exchange factor
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHR aryl hydrocarbon receptor
ARPC5L actin related protein 2/3 complex, subunit 5-like
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP3 dual specificity phosphatase 3
EREG epiregulin
GADD45B growth arrest and DNA-damage-inducible, beta
GRWD1 glutamate-rich WD repeat containing 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA1033 KIAA1033
KLF4 Kruppel-like factor 4 (gut)
LMO2 LIM domain only 2 (rhombotin-like 1)
MCUR1 mitochondrial calcium uniporter regulator 1
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MSL2 male-specific lethal 2 homolog (Drosophila)
NIP7 NIP7, nucleolar pre-rRNA processing protein
PLAC8 placenta-specific 8
PPAT phosphoribosyl pyrophosphate amidotransferase
PROSC proline synthetase co-transcribed homolog (bacterial)
PSCA prostate stem cell antigen
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TBX2 T-box 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TSC22D2 TSC22 domain family, member 2
ZCCHC14 zinc finger, CCHC domain containing 14