BRD-K55116708_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

323 genes differentially expressed following the BRD-K55116708_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
AIM1 absent in melanoma 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDOB aldolase B, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
APOD apolipoprotein D
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CLDN5 claudin 5
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CORO1A coronin, actin binding protein, 1A
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENAH enabled homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FBLN2 fibulin 2
FN1 fibronectin 1
FOXO4 forkhead box O4
FSTL1 follistatin-like 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD6 FXYD domain containing ion transport regulator 6
FZD2 frizzled class receptor 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNS glucosamine (N-acetyl)-6-sulfatase
GSDMB gasdermin B
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYG2 glycogenin 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL32 interleukin 32
INA internexin neuronal intermediate filament protein, alpha
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITM2C integral membrane protein 2C
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
L1CAM L1 cell adhesion molecule
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL2 lysyl oxidase-like 2
LPIN1 lipin 1
MAP1B microtubule-associated protein 1B
MFAP2 microfibrillar-associated protein 2
MMD monocyte to macrophage differentiation-associated
MMP11 matrix metallopeptidase 11
MSN moesin
MSX1 msh homeobox 1
MVP major vault protein
MYO1B myosin IB
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
PALLD palladin, cytoskeletal associated protein
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PLS1 plastin 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POR P450 (cytochrome) oxidoreductase
PRSS8 protease, serine, 8
PSAP prosaposin
PYGL phosphorylase, glycogen, liver
RAB29 RAB29, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
REEP1 receptor accessory protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRAS related RAS viral (r-ras) oncogene homolog
RTN1 reticulon 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SELENBP1 selenium binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SPTSSA serine palmitoyltransferase, small subunit A
SST somatostatin
STC1 stanniocalcin 1
STMN2 stathmin 2
STOM stomatin
STON1 stonin 1
STXBP1 syntaxin binding protein 1
SYT1 synaptotagmin I
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TM4SF20 transmembrane 4 L six family member 20
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIM2 tripartite motif containing 2
TSPAN3 tetraspanin 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VCL vinculin
VIM vimentin
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ATF5 activating transcription factor 5
AURKA aurora kinase A
AXIN1 axin 1
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BUB3 BUB3 mitotic checkpoint protein
C1QBP complement component 1, q subcomponent binding protein
CA12 carbonic anhydrase XII
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ENOPH1 enolase-phosphatase 1
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
FAM35A family with sequence similarity 35, member A
FAM57A family with sequence similarity 57, member A
FANCI Fanconi anemia, complementation group I
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GATA3 GATA binding protein 3
GCAT glycine C-acetyltransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMDS GDP-mannose 4,6-dehydratase
GRWD1 glutamate-rich WD repeat containing 1
HMGB2 high mobility group box 2
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
LOC81691 exonuclease NEF-sp
LONP2 lon peptidase 2, peroxisomal
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MRPS30 mitochondrial ribosomal protein S30
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMB microseminoprotein, beta-
MYCBP MYC binding protein
NAT10 N-acetyltransferase 10 (GCN5-related)
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1IP1 PAK1 interacting protein 1
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRPF19 pre-mRNA processing factor 19
QDPR quinoid dihydropteridine reductase
RAD51 RAD51 recombinase
RFC3 replication factor C (activator 1) 3, 38kDa
RGS1 regulator of G-protein signaling 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAC3D1 SAC3 domain containing 1
SEH1L SEH1-like (S. cerevisiae)
SHCBP1 SHC SH2-domain binding protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SPAG5 sperm associated antigen 5
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TDP1 tyrosyl-DNA phosphodiesterase 1
TFB2M transcription factor B2, mitochondrial
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TP53 tumor protein p53
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein