BRD-K55116708_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K55116708_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA1 annexin A1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIK BCL2-interacting killer (apoptosis-inducing)
BPHL biphenyl hydrolase-like (serine hydrolase)
C3 complement component 3
CD24 CD24 molecule
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
GPC4 glypican 4
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIST1H2AC histone cluster 1, H2ac
IL17RB interleukin 17 receptor B
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LCN2 lipocalin 2
LMO3 LIM domain only 3 (rhombotin-like 2)
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
PCSK1 proprotein convertase subtilisin/kexin type 1
PLAU plasminogen activator, urokinase
PTPRO protein tyrosine phosphatase, receptor type, O
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RNF167 ring finger protein 167
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STX1A syntaxin 1A (brain)
TAGLN2 transgelin 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS3 tensin 3
TPD52 tumor protein D52
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CBR3 carbonyl reductase 3
CXCL12 chemokine (C-X-C motif) ligand 12
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FBXO21 F-box protein 21
HOXA5 homeobox A5
HOXB6 homeobox B6
HOXC6 homeobox C6
LBR lamin B receptor
LRRC16A leucine rich repeat containing 16A
PPIF peptidylprolyl isomerase F
QKI QKI, KH domain containing, RNA binding
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TSPAN8 tetraspanin 8
ZBTB18 zinc finger and BTB domain containing 18