BRD-K54997624_BYL719_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K54997624_BYL719_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
CAV1 caveolin 1, caveolae protein, 22kDa
CD9 CD9 molecule
CFD complement factor D (adipsin)
CXCL13 chemokine (C-X-C motif) ligand 13
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
FAM63A family with sequence similarity 63, member A
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLUL glutamate-ammonia ligase
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HLA-DMA major histocompatibility complex, class II, DM alpha
IFITM1 interferon induced transmembrane protein 1
LCN2 lipocalin 2
LOC100272216 uncharacterized LOC100272216
LXN latexin
LYPD3 LY6/PLAUR domain containing 3
MME membrane metallo-endopeptidase
MTUS1 microtubule associated tumor suppressor 1
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NBPF10 neuroblastoma breakpoint family, member 10
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCNA proliferating cell nuclear antigen
PERP PERP, TP53 apoptosis effector
PLBD1 phospholipase B domain containing 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RPL31 ribosomal protein L31
S100P S100 calcium binding protein P
SCARB2 scavenger receptor class B, member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SOD2 superoxide dismutase 2, mitochondrial
TMPRSS3 transmembrane protease, serine 3
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CX3CR1 chemokine (C-X3-C motif) receptor 1
EPCAM epithelial cell adhesion molecule
FOXG1 forkhead box G1
GLIPR1 GLI pathogenesis-related 1
HSPA1A heat shock 70kDa protein 1A
IGL immunoglobulin lambda locus
KIF20A kinesin family member 20A
LBR lamin B receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
LYN LYN proto-oncogene, Src family tyrosine kinase
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
NPY1R neuropeptide Y receptor Y1
PARP2 poly (ADP-ribose) polymerase 2
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBBP8 retinoblastoma binding protein 8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TMEM47 transmembrane protein 47
TPX2 TPX2, microtubule-associated
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
UBE2S ubiquitin-conjugating enzyme E2S
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VCAN versican