BRD-K54997624_BYL719_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-K54997624_BYL719_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CD44 CD44 molecule (Indian blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
COMP cartilage oligomeric matrix protein
CTSZ cathepsin Z
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
EIF5A eukaryotic translation initiation factor 5A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GAA glucosidase, alpha; acid
GFOD1 glucose-fructose oxidoreductase domain containing 1
KRT7 keratin 7, type II
MAGEA3 melanoma antigen family A3
MT1H metallothionein 1H
MT1X metallothionein 1X
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PTPRO protein tyrosine phosphatase, receptor type, O
RHOB ras homolog family member B
SPATA20 spermatogenesis associated 20
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTSSA serine palmitoyltransferase, small subunit A
SRPX sushi-repeat containing protein, X-linked
TIMP3 TIMP metallopeptidase inhibitor 3
TRIB2 tribbles pseudokinase 2
VGLL1 vestigial-like family member 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARG1 arginase 1
BLNK B-cell linker
C4BPA complement component 4 binding protein, alpha
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CXCL14 chemokine (C-X-C motif) ligand 14
DLX2 distal-less homeobox 2
DNM1L dynamin 1-like
EMX2 empty spiracles homeobox 2
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
IFI30 interferon, gamma-inducible protein 30
IL7R interleukin 7 receptor
MNDA myeloid cell nuclear differentiation antigen
NCAM1 neural cell adhesion molecule 1
NPY1R neuropeptide Y receptor Y1
P3H2 prolyl 3-hydroxylase 2
RAB31 RAB31, member RAS oncogene family
SCD5 stearoyl-CoA desaturase 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TM9SF3 transmembrane 9 superfamily member 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
YME1L1 YME1-like 1 ATPase