BRD-K54997624_BYL719_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K54997624_BYL719_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ANKRD10 ankyrin repeat domain 10
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD46 CD46 molecule, complement regulatory protein
CDC42 cell division cycle 42
CHMP1B charged multivesicular body protein 1B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL10A1 collagen, type X, alpha 1
DAPK1 death-associated protein kinase 1
DCN decorin
DRAM1 DNA-damage regulated autophagy modulator 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM63A family with sequence similarity 63, member A
FMO5 flavin containing monooxygenase 5
FOXO4 forkhead box O4
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GRN granulin
H3F3B H3 histone, family 3B (H3.3B)
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H4J histone cluster 1, H4j
IFITM1 interferon induced transmembrane protein 1
IFNGR1 interferon gamma receptor 1
IRS2 insulin receptor substrate 2
ISCU iron-sulfur cluster assembly enzyme
KIAA1033 KIAA1033
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LGALS3 lectin, galactoside-binding, soluble, 3
LXN latexin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MPO myeloperoxidase
MVP major vault protein
MYB v-myb avian myeloblastosis viral oncogene homolog
MYLIP myosin regulatory light chain interacting protein
NBR1 neighbor of BRCA1 gene 1
PAWR PRKC, apoptosis, WT1, regulator
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PYCARD PYD and CARD domain containing
RAB31 RAB31, member RAS oncogene family
RBM47 RNA binding motif protein 47
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SKAP2 src kinase associated phosphoprotein 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
STAR steroidogenic acute regulatory protein
STAT5B signal transducer and activator of transcription 5B
STS steroid sulfatase (microsomal), isozyme S
TRAM1 translocation associated membrane protein 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
VCAN versican
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ADAM19 ADAM metallopeptidase domain 19
ADGRL2 adhesion G protein-coupled receptor L2
ARMCX2 armadillo repeat containing, X-linked 2
BZW2 basic leucine zipper and W2 domains 2
CA2 carbonic anhydrase II
CALR calreticulin
CD24 CD24 molecule
CDC7 cell division cycle 7
CKB creatine kinase, brain
DLD dihydrolipoamide dehydrogenase
DOK5 docking protein 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXG1 forkhead box G1
G0S2 G0/G1 switch 2
GAGE3 G antigen 3
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
GSPT2 G1 to S phase transition 2
HES1 hes family bHLH transcription factor 1
HOXC10 homeobox C10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0101 KIAA0101
LIMCH1 LIM and calponin homology domains 1
LIPG lipase, endothelial
LPL lipoprotein lipase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MECOM MDS1 and EVI1 complex locus
MT1E metallothionein 1E
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NFIB nuclear factor I/B
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUSAP1 nucleolar and spindle associated protein 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PFKP phosphofructokinase, platelet
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PTPRO protein tyrosine phosphatase, receptor type, O
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOAT1 sterol O-acyltransferase 1
SSX1 synovial sarcoma, X breakpoint 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)