BRD-K54606188_(+)-JQ1_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-K54606188_(+)-JQ1_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AREG amphiregulin
ATF3 activating transcription factor 3
BGN biglycan
CA2 carbonic anhydrase II
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPA3 carboxypeptidase A3 (mast cell)
CREG1 cellular repressor of E1A-stimulated genes 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSK cathepsin K
DLX2 distal-less homeobox 2
DMXL2 Dmx-like 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP22 dual specificity phosphatase 22
DUSP6 dual specificity phosphatase 6
FERMT2 fermitin family member 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPM6B glycoprotein M6B
GPR137B G protein-coupled receptor 137B
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGKC immunoglobulin kappa constant
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INPP5F inositol polyphosphate-5-phosphatase F
ITGA6 integrin, alpha 6
KLF10 Kruppel-like factor 10
LAPTM4B lysosomal protein transmembrane 4 beta
LPIN1 lipin 1
LRRC15 leucine rich repeat containing 15
MACF1 microtubule-actin crosslinking factor 1
MAP1A microtubule-associated protein 1A
MFAP3L microfibrillar-associated protein 3-like
MMP1 matrix metallopeptidase 1
NDN necdin, melanoma antigen (MAGE) family member
NEFL neurofilament, light polypeptide
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
PALLD palladin, cytoskeletal associated protein
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PBX3 pre-B-cell leukemia homeobox 3
PDZD8 PDZ domain containing 8
PEG3 paternally expressed 3
PLK2 polo-like kinase 2
PNKP polynucleotide kinase 3'-phosphatase
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHOB ras homolog family member B
RRAGD Ras-related GTP binding D
RUFY3 RUN and FYVE domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPT10 septin 10
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SF1 splicing factor 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SST somatostatin
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP1 syntaxin binding protein 1
TPD52L1 tumor protein D52-like 1
TPST2 tyrosylprotein sulfotransferase 2
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
VCL vinculin
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB18 zinc finger and BTB domain containing 18
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACP2 acid phosphatase 2, lysosomal
ADGRG1 adhesion G protein-coupled receptor G1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOC2 apolipoprotein C-II
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
C3 complement component 3
CA1 carbonic anhydrase I
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC86 coiled-coil domain containing 86
CD58 CD58 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFI complement factor I
CLCA4 chloride channel accessory 4
COL4A2 collagen, type IV, alpha 2
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
FAM129A family with sequence similarity 129, member A
GOLT1B golgi transport 1B
GPR171 G protein-coupled receptor 171
GYPC glycophorin C (Gerbich blood group)
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB1 heat shock 27kDa protein 1
ICAM3 intercellular adhesion molecule 3
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL27RA interleukin 27 receptor, alpha
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JADE2 jade family PHD finger 2
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LOX lysyl oxidase
LPL lipoprotein lipase
MAL mal, T-cell differentiation protein
MANSC1 MANSC domain containing 1
MAPK13 mitogen-activated protein kinase 13
MGST2 microsomal glutathione S-transferase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL2 myelin protein zero-like 2
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIP prolactin-induced protein
POSTN periostin, osteoblast specific factor
PPL periplakin
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAD23B RAD23 homolog B (S. cerevisiae)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCC1 regulator of chromosome condensation 1
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SCD5 stearoyl-CoA desaturase 5
SCEL sciellin
SEPT9 septin 9
SFRP1 secreted frizzled-related protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC43A3 solute carrier family 43, member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STEAP1 six transmembrane epithelial antigen of the prostate 1
TF transferrin
TM4SF1 transmembrane 4 L six family member 1
TRIM2 tripartite motif containing 2
TSPAN4 tetraspanin 4
VCAN versican