BRD-K54606188_(+)-JQ1_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K54606188_(+)-JQ1_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ANXA4 annexin A4
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP29 Rho GTPase activating protein 29
CD24 CD24 molecule
CIRBP cold inducible RNA binding protein
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
FBP1 fructose-1,6-bisphosphatase 1
FN1 fibronectin 1
GGT1 gamma-glutamyltransferase 1
H2BFS H2B histone family, member S (pseudogene)
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IFI27 interferon, alpha-inducible protein 27
IL33 interleukin 33
KCTD12 potassium channel tetramerization domain containing 12
LGALS3 lectin, galactoside-binding, soluble, 3
MOAP1 modulator of apoptosis 1
MTSS1 metastasis suppressor 1
NDRG1 N-myc downstream regulated 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX3 pre-B-cell leukemia homeobox 3
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SEPP1 selenoprotein P, plasma, 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SQSTM1 sequestosome 1
STXBP1 syntaxin binding protein 1
TATDN2 TatD DNase domain containing 2
TIMP1 TIMP metallopeptidase inhibitor 1
TOMM34 translocase of outer mitochondrial membrane 34
TRAPPC6A trafficking protein particle complex 6A
TXNIP thioredoxin interacting protein
VIM vimentin

decreased expression

Symbol Name
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BTG3 BTG family, member 3
C1QB complement component 1, q subcomponent, B chain
CALB1 calbindin 1, 28kDa
CD200 CD200 molecule
CD34 CD34 molecule
CDC20 cell division cycle 20
CEMIP cell migration inducing protein, hyaluronan binding
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COTL1 coactosin-like F-actin binding protein 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL2 four and a half LIM domains 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM3 intercellular adhesion molecule 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KRT13 keratin 13, type I
KRT81 keratin 81, type II
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MXRA5 matrix-remodelling associated 5
MYO5C myosin VC
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCH protein kinase C, eta
PRSS2 protease, serine, 2 (trypsin 2)
PXDN peroxidasin
RGS1 regulator of G-protein signaling 1
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMP3 TIMP metallopeptidase inhibitor 3
TRBC1 T cell receptor beta constant 1