BRD-K54606188_(+)-JQ1_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K54606188_(+)-JQ1_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASPH aspartate beta-hydroxylase
BASP1 brain abundant, membrane attached signal protein 1
BZW2 basic leucine zipper and W2 domains 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANX calnexin
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIRBP cold inducible RNA binding protein
CLTA clathrin, light chain A
CORO1C coronin, actin binding protein, 1C
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CTSB cathepsin B
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP10 dual specificity phosphatase 10
EPAS1 endothelial PAS domain protein 1
FAM46A family with sequence similarity 46, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FUCA1 fucosidase, alpha-L- 1, tissue
GSN gelsolin
HSPA1A heat shock 70kDa protein 1A
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LGMN legumain
LYZ lysozyme
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MTSS1 metastasis suppressor 1
NBPF10 neuroblastoma breakpoint family, member 10
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OAT ornithine aminotransferase
PDLIM5 PDZ and LIM domain 5
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTPRC protein tyrosine phosphatase, receptor type, C
RGS13 regulator of G-protein signaling 13
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SWAP70 SWAP switching B-cell complex 70kDa subunit
TPD52L1 tumor protein D52-like 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ADGRA2 adhesion G protein-coupled receptor A2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCHE butyrylcholinesterase
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CD200 CD200 molecule
CD34 CD34 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKAP4 cytoskeleton-associated protein 4
COL1A2 collagen, type I, alpha 2
DUSP2 dual specificity phosphatase 2
EFS embryonal Fyn-associated substrate
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FKBP11 FK506 binding protein 11, 19 kDa
IGF1 insulin-like growth factor 1 (somatomedin C)
JMJD6 jumonji domain containing 6
MME membrane metallo-endopeptidase
NREP neuronal regeneration related protein
NUP85 nucleoporin 85kDa
P3H2 prolyl 3-hydroxylase 2
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGIS prostaglandin I2 (prostacyclin) synthase
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
ZW10 zw10 kinetochore protein