BRD-K54606188_(+)-JQ1_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K54606188_(+)-JQ1_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZW2 basic leucine zipper and W2 domains 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC92 coiled-coil domain containing 92
CCL21 chemokine (C-C motif) ligand 21
CD44 CD44 molecule (Indian blood group)
CLEC3B C-type lectin domain family 3, member B
CLIC3 chloride intracellular channel 3
CSRP2 cysteine and glycine-rich protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGR1 early growth response 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FERMT2 fermitin family member 2
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL1 four and a half LIM domains 1
FSTL1 follistatin-like 1
G0S2 G0/G1 switch 2
GPM6B glycoprotein M6B
GRB14 growth factor receptor-bound protein 14
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
KIF2C kinesin family member 2C
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKS myristoylated alanine-rich protein kinase C substrate
MNAT1 MNAT CDK-activating kinase assembly factor 1
NMT2 N-myristoyltransferase 2
NOTCH2NL notch 2 N-terminal like
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
QKI QKI, KH domain containing, RNA binding
RND3 Rho family GTPase 3
SCAF4 SR-related CTD-associated factor 4
SCGB2A2 secretoglobin, family 2A, member 2
SMAD7 SMAD family member 7
STC2 stanniocalcin 2
TAGLN transgelin
TCF4 transcription factor 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM50A transmembrane protein 50A
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBA1A tubulin, alpha 1a
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABLIM1 actin binding LIM protein 1
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOL3 apolipoprotein L, 3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE41 basic helix-loop-helix family, member e41
CA12 carbonic anhydrase XII
CD200 CD200 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLEC5A C-type lectin domain family 5, member A
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
CYTIP cytohesin 1 interacting protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFBP1 fibroblast growth factor binding protein 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GBP2 guanylate binding protein 2, interferon-inducible
HAPLN1 hyaluronan and proteoglycan link protein 1
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
IL17RB interleukin 17 receptor B
IL1R2 interleukin 1 receptor, type II
KIZ kizuna centrosomal protein
KRT18 keratin 18, type I
MAMLD1 mastermind-like domain containing 1
MAPK13 mitogen-activated protein kinase 13
MMP9 matrix metallopeptidase 9
MSLN mesothelin
NKX3-1 NK3 homeobox 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
PDIA3 protein disulfide isomerase family A, member 3
PLAC8 placenta-specific 8
PRKCA protein kinase C, alpha
PRR5 proline rich 5 (renal)
PRUNE2 prune homolog 2 (Drosophila)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAD23B RAD23 homolog B (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHB Src homology 2 domain containing adaptor protein B
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORBS3 sorbin and SH3 domain containing 3
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SPRR3 small proline-rich protein 3
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST5 suppression of tumorigenicity 5
TARP TCR gamma alternate reading frame protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TXNIP thioredoxin interacting protein
VSIG4 V-set and immunoglobulin domain containing 4
WT1 Wilms tumor 1