BRD-K54606188_(+)-JQ1_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K54606188_(+)-JQ1_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK1 adenylate kinase 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCDC92 coiled-coil domain containing 92
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CLGN calmegin
CPNE3 copine III
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLD dihydrolipoamide dehydrogenase
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ENAH enabled homolog (Drosophila)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GLO1 glyoxalase I
GPX4 glutathione peroxidase 4
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IFI27 interferon, alpha-inducible protein 27
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LDOC1 leucine zipper, down-regulated in cancer 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1X metallothionein 1X
NEBL nebulette
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PNN pinin, desmosome associated protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRAF2 PRA1 domain family, member 2
PRDX2 peroxiredoxin 2
PSENEN presenilin enhancer gamma secretase subunit
RGS4 regulator of G-protein signaling 4
RHOA ras homolog family member A
RTN3 reticulon 3
S100A2 S100 calcium binding protein A2
SCAND1 SCAN domain containing 1
SDCBP syndecan binding protein (syntenin)
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SQSTM1 sequestosome 1
STXBP1 syntaxin binding protein 1
SYT11 synaptotagmin XI
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM50A transmembrane protein 50A
TPD52L1 tumor protein D52-like 1
TPST2 tyrosylprotein sulfotransferase 2
TRIM33 tripartite motif containing 33
TUBA1A tubulin, alpha 1a
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCL vinculin
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ANK2 ankyrin 2, neuronal
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
BATF3 basic leucine zipper transcription factor, ATF-like 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CD48 CD48 molecule
CDK18 cyclin-dependent kinase 18
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP55 centrosomal protein 55kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLEC2B C-type lectin domain family 2, member B
COL4A2 collagen, type IV, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DFNA5 deafness, autosomal dominant 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ELP5 elongator acetyltransferase complex subunit 5
EPHA3 EPH receptor A3
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GBP1 guanylate binding protein 1, interferon-inducible
GEMIN4 gem (nuclear organelle) associated protein 4
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HK2 hexokinase 2
HMGA1 high mobility group AT-hook 1
HOXB7 homeobox B7
IFI16 interferon, gamma-inducible protein 16
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KLF4 Kruppel-like factor 4 (gut)
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM2 minichromosome maintenance complex component 2
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
MZB1 marginal zone B and B1 cell-specific protein
NMI N-myc (and STAT) interactor
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RAB20 RAB20, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
RSL1D1 ribosomal L1 domain containing 1
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SNX10 sorting nexin 10
SPATS2L spermatogenesis associated, serine-rich 2-like
SPTBN1 spectrin, beta, non-erythrocytic 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM97 transmembrane protein 97
TRIM14 tripartite motif containing 14
TYRO3 TYRO3 protein tyrosine kinase
VCAN versican