BRD-K54606188_(+)-JQ1_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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45 genes differentially expressed following the BRD-K54606188_(+)-JQ1_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADI1 acireductone dioxygenase 1
CCDC85B coiled-coil domain containing 85B
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
F3 coagulation factor III (thromboplastin, tissue factor)
FZD7 frizzled class receptor 7
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
IFI27 interferon, alpha-inducible protein 27
MCAM melanoma cell adhesion molecule
NDRG1 N-myc downstream regulated 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
SORL1 sortilin-related receptor, L(DLR class) A repeats containing

decreased expression

Symbol Name
ARL4C ADP-ribosylation factor-like 4C
C5 complement component 5
CCL2 chemokine (C-C motif) ligand 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CP ceruloplasmin (ferroxidase)
FN1 fibronectin 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
KRT19 keratin 19, type I
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
MLPH melanophilin
MMP7 matrix metallopeptidase 7
NNMT nicotinamide N-methyltransferase
NPAS2 neuronal PAS domain protein 2
NTS neurotensin
PDLIM5 PDZ and LIM domain 5
POSTN periostin, osteoblast specific factor
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RGS2 regulator of G-protein signaling 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SNAP25 synaptosomal-associated protein, 25kDa
SORBS3 sorbin and SH3 domain containing 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TNNT1 troponin T type 1 (skeletal, slow)
VAV3 vav 3 guanine nucleotide exchange factor