BRD-K54606188_(+)-JQ1_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K54606188_(+)-JQ1_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
ATF3 activating transcription factor 3
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C8ORF4 chromosome 8 open reading frame 4
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPG capping protein (actin filament), gelsolin-like
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CD24 CD24 molecule
CD81 CD81 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CH25H cholesterol 25-hydroxylase
CPA3 carboxypeptidase A3 (mast cell)
CTH cystathionine gamma-lyase
CTSK cathepsin K
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP10 dual specificity phosphatase 10
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
G6PD glucose-6-phosphate dehydrogenase
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
JAG1 jagged 1
KIAA0226L KIAA0226-like
LBH limb bud and heart development
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SQSTM1 sequestosome 1
SST somatostatin
THBD thrombomodulin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM7SF2 transmembrane 7 superfamily member 2
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
UBXN4 UBX domain protein 4
VEZF1 vascular endothelial zinc finger 1
VSNL1 visinin-like 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA10 annexin A10
APOD apolipoprotein D
CCL5 chemokine (C-C motif) ligand 5
CD52 CD52 molecule
CLEC2B C-type lectin domain family 2, member B
CRELD2 cysteine-rich with EGF-like domains 2
CYB561 cytochrome b561
FHL1 four and a half LIM domains 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GRIA2 glutamate receptor, ionotropic, AMPA 2
GYPC glycophorin C (Gerbich blood group)
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXB7 homeobox B7
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB1 heat shock 27kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL17RB interleukin 17 receptor B
IL2RB interleukin 2 receptor, beta
IQGAP2 IQ motif containing GTPase activating protein 2
JADE2 jade family PHD finger 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MEIS2 Meis homeobox 2
MOK MOK protein kinase
MPPED2 metallophosphoesterase domain containing 2
MRPL12 mitochondrial ribosomal protein L12
MRPL19 mitochondrial ribosomal protein L19
NID1 nidogen 1
NRN1 neuritin 1
PCOLCE procollagen C-endopeptidase enhancer
PCP4 Purkinje cell protein 4
PDIA3 protein disulfide isomerase family A, member 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRAME preferentially expressed antigen in melanoma
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSPH phosphoserine phosphatase
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCGB1D2 secretoglobin, family 1D, member 2
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLPI secretory leukocyte peptidase inhibitor
SOX11 SRY (sex determining region Y)-box 11
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STC2 stanniocalcin 2
TCAF1 TRPM8 channel-associated factor 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TPM1 tropomyosin 1 (alpha)
TSPAN4 tetraspanin 4
TUSC3 tumor suppressor candidate 3
VDAC1 voltage-dependent anion channel 1
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1