BRD-K54256913_MK-1775_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K54256913_MK-1775_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BAZ2B bromodomain adjacent to zinc finger domain, 2B
CDC20 cell division cycle 20
CYR61 cysteine-rich, angiogenic inducer, 61
EGR1 early growth response 1
EPHB2 EPH receptor B2
IGFBP7 insulin-like growth factor binding protein 7
IRF8 interferon regulatory factor 8
LAP3 leucine aminopeptidase 3
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MARCKSL1 MARCKS-like 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1M metallothionein 1M
PCGF2 polycomb group ring finger 2
PLA2G16 phospholipase A2, group XVI
PRDX2 peroxiredoxin 2
PROM1 prominin 1
PTCH1 patched 1
RHOBTB3 Rho-related BTB domain containing 3
S100A12 S100 calcium binding protein A12
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TFF1 trefoil factor 1
TIMP1 TIMP metallopeptidase inhibitor 1
TOX3 TOX high mobility group box family member 3
VCAN versican
ZBTB20 zinc finger and BTB domain containing 20
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRL2 adhesion G protein-coupled receptor L2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP3M2 adaptor-related protein complex 3, mu 2 subunit
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CA12 carbonic anhydrase XII
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DSP desmoplakin
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
FAM60A family with sequence similarity 60, member A
GLS glutaminase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
KRT19 keratin 19, type I
LUM lumican
MBP myelin basic protein
MME membrane metallo-endopeptidase
MOXD1 monooxygenase, DBH-like 1
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
MYO1B myosin IB
PBX1 pre-B-cell leukemia homeobox 1
PRKCI protein kinase C, iota
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
VIM vimentin