BRD-K54256913_MK-1775_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K54256913_MK-1775_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG1 adhesion G protein-coupled receptor G1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CCND2 cyclin D2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN4 claudin 4
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT4 DNA-damage-inducible transcript 4
DNM3 dynamin 3
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHA3 EPH receptor A3
EPS8L2 EPS8-like 2
FAM129A family with sequence similarity 129, member A
FAM63A family with sequence similarity 63, member A
FBN2 fibrillin 2
FDXR ferredoxin reductase
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GPX1 glutathione peroxidase 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
ICAM1 intercellular adhesion molecule 1
INPP1 inositol polyphosphate-1-phosphatase
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LRP10 low density lipoprotein receptor-related protein 10
MAP1B microtubule-associated protein 1B
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A11 S100 calcium binding protein A11
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SCRN1 secernin 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT3 sirtuin 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST18 suppression of tumorigenicity 18, zinc finger
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TMPRSS2 transmembrane protease, serine 2
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CHEK1 checkpoint kinase 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLC Charcot-Leyden crystal galectin
CXCL12 chemokine (C-X-C motif) ligand 12
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCK deoxycytidine kinase
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
FEN1 flap structure-specific endonuclease 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HBB hemoglobin, beta
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HELLS helicase, lymphoid-specific
HMGB2 high mobility group box 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KLF4 Kruppel-like factor 4 (gut)
LPIN1 lipin 1
LPL lipoprotein lipase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MSH6 mutS homolog 6
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
OPN3 opsin 3
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RGS5 regulator of G-protein signaling 5
RPA1 replication protein A1, 70kDa
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
STC1 stanniocalcin 1
STMN1 stathmin 1
TCTN1 tectonic family member 1
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein